Serial radical cyclization via a vinyl group immobilized by a pyranoside. A route to bis-annulated pyranosides; Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases

2022年11月12日 · We report a novel method to synthesize degradable poly (vinyl ether)s with cleavable thioacetal bonds periodically arranged in the main chains using controlled cationic copolymerization of vinyl ethers with a 7-membered cyclic thioacetal (7-CTA) via degenerative chain transfer (DT) to the internal thioacetal bonds.

2017年2月1日 · Ring-driven physical properties of cyclic poly (vinyl ether)s were studied, such as thermal sensitivity in solution and glass transition temperature (Tg). The samples were …

1981年1月1日 · Conditions for metalation of a variety of cyclic vinyl ethers and reaction of the resulting carbanions with electrophiles are described. Effects of the vinyl ether structure on the relative rates of metalation are discussed. Applications of this methodology to the construction of various types of carbonyl compounds are presented.

2017年11月5日 · Free-radical copolymerization of cyclic ketene acetals (CKAs) and vinyl ethers (VEs) was investigated as an efficient yet simple approach for the preparation of functional aliphatic polyesters. The copolymerization of CKA and VE was first predicted to be quasi-ideal by DFT calculations.

2013年6月3日 · In this paper, we provide an effective route to cyclopolymers via the Lewis acid-assisted “ring-expansion” living cationic polymerization of vinyl ethers, directly from a simple “cyclic initiator” designed with a hemiacetal ester for …

2016年3月2日 · In this review, our recent results on the concurrent cationic vinyl-addition and ring-opening copolymerization of vinyl ethers (VEs) and oxiranes are summarized, with particular emphasis on...

2022年7月21日 · Cyclic vinyl ethers with acetal linkage were derived from glycerol to yield well-defined copolymers by reversible addition-fragmentation chain transfer (RAFT) radical copolymerization with common vinyl monomers.

2009年3月28日 · The resulting allyl vinyl ethers were expected to undergo [3,3] shift to form eight-membered cyclic products. In this paper, we wish to report our results on the investigation of PtCl 2-catalyzed isomerization of alkynyl epoxides and an alkynyl allyl alcohol, and the [3,3] sigmatropic shift of the resulting cyclic allyl vinyl ethers.

Schappacher and Deffieux, in 1991, provided a very early example of successful cyclization of poly(2-chloroethyl vinyl ether) (PCEVE) by heterocoupling. The α -styrenyl, ω -iodo linear PCEVE precursor was prepared by cationic polymerization of the corresponding monomer from a vinyl ether-functionalized styrene initiator.