Cyclam (1,4,8,11-tetraazacyclotetradecane) is an organic compound with the formula (NHCH 2 CH 2 NHCH 2 CH 2 CH 2) 2. Classified as an aza-crown ether, it is a white solid that is soluble in water. As a macrocyclic ligand, it binds strongly to many transition metal cations. [1]

Cyclam is a metal chelator that forms metal complexes with a variety of metal ions. Cyclam metal complexes exhibits anti-HIV (such as AMD3100), nitric oxide (NO) releasing and scavenging (such as Zn(II)-Cyclam and Ru(II)-Cyclam), and SOD mimetic (such as Mn(III)-Cyclam and Zn(II)-Cyclam) activities.

它是一种 氮杂冠醚 （英语：aza-crown ether），外观为可溶于水的白色固体。 作为一种 大环 配体，它与许多过渡金属 阳离子 强烈结合。 [1] 这种化合物的首次制备是通过 1,3-二溴丙烷 和 乙二胺 的反应而成的。 [2] 1,4,8,11-四氮杂环十四烷有四个 仲胺。 因此，它的配合物有多种 非对映异构体，具体取决于 N-H 中心的相对取向。 1,4,8,11-四氮杂环十四烷的配合物具有交替的五元和六元螯合环。 紧密相关的配体 1,4,7,10-四氮杂环十二烷 ( (CH 2 CH 2 NH) 4) 只会形成 C 2 N 2 …

Cyclam | C10H24N4 | CID 64964 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Aldrich-259160; 1,4,8,11-Tetraazacyclotetradecane 98% (GC); CAS No.: 295-37-4; Synonyms: Cyclam; Linear Formula: C10H24N4; Empirical Formula: C10H24N4; find related products, papers, technical documents, MSDS & more at Sigma-Aldrich.

1,4,8,11-四氮杂环十四烷(cyclam)可作为配体用于合成： 氰化物桥联Fe III -Cu II 配合物。 具有抗菌性的芬那酸锌配合物[Zn(cyclam)(fen) 2 ]，fen=芬那酸。

Herein we report the results of preparing metal compounds (where the metal ions are Co, Ni, Cu, Zn) with the cyclic ligand 1,4,8,11-tetraazacyclotetradecane [cyclam] under a variety of conditions of metal-ligand ratios and solvent media. In all cases, we used metal Cl O salts (except for anhydrous CoCl), as specified.

Cyclam (1,4,8,11-tetraazacyclotetradecane) is an organic compound. It is a white solid that is soluble in water. The compound is notable as a macrocyclic ligand, which binds strongly to many transition metal cations. The compound was first prepared by the reaction of 1,3-dibromopropane and ethylenediamine.

The backbones of macrocyclic amino chelators are cyclam (1,4,8,11-tetra azacyclotetradecane) and cyclen (1,4,7,10-tetraazacyclododecane). Both of them demonstrated an extreme high affinity constant for copper, log K l, found to be greater than 27. However, the powerful chelator for copper, cyclam failed to inhibit Cu,Zn-SOD activity [26]. In ...

ChemSpider record containing structure, synonyms, properties, vendors and database links for Cyclam, 295-37-4, 111811, MDAXKAUIABOHTD-UHFFFAOYSA-N