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2024年7月1日 · To enhance the tumor-specific targeting, we employ a bioorthogonal approach to engineer CuSA, denoted as CuSACO. CuSACO not only exhibits minimal off-target toxicity but also possesses exceptional ultrahigh catalase-, oxidase-, peroxidase-like multienzyme activities, resulting in reactive oxygen species (ROS) storm generation for effective ...

2024年4月23日 · We have developed bioorthogonal Cu single atom nanozyme (CuSACO) for specifically tumor-targeting and photoacoustic (PA) imaging-guided tumor multifunctional therapy including high-efficiency multienzyme catalytic activities (catalase (CAT), oxidase (OXD), peroxidase (POD)), photothermal therapy (PTT), cuproptosis and immunogenic cell death ...

Imaging and multifunctional therapy of CuSACO in tumor cells. (a) Fluorescence images of 4T1 cells incubated with indicated treatments. Group I: CuSACO/Cy5.5 (5 μM Cy5.5), Group II:...

我们开发了生物正交铜单原子纳米酶（CuSACO），专门用于肿瘤靶向和光声（PA）成像引导的肿瘤多功能治疗，包括高效多酶催化活性（过氧化氢酶（CAT）、氧化酶（OXD）、过氧化物酶（POD）） 、光热疗法（PTT）、铜凋亡和免疫原性细胞死亡（ICD）为主的免疫疗法，有效抑制肿瘤的生长、转移和复发。

Andrew Cusack, also known as André Cusaco, was an Irish colonial administrator at the service of Portugal. He was appointed governor of Rio de Janeiro on 29 August 1694, replacing the prior holder of the office, António Pais de Sande, who had suffered a stroke .

2024年4月23日 · To enhance the tumor-specific targeting, we employ a bioorthogonal approach to engineer CuSA, denoted as CuSACO. CuSACO not only exhibits minimal off-target toxicity but also possesses exceptional ultrahigh catalase-, oxidase-, peroxidase-like multienzyme activities, resulting in reactive oxygen species (ROS) storm generation for effective ...

Guided by PA imaging with high‐resolution and deep tissue penetration, CuSACO initiates a high‐efficiency catalytic activities triggered by the acidic tumor microenvironment and intracellular...

Information and translations of Cusaco in the most comprehensive dictionary definitions resource on the web.

2024年5月10日 · 为了增强对肿瘤的特异性靶向，研究者采用了一种生物正交方法对cusa进行改造，从而制备了cusaco。 研究发现，CuSACO不仅具有极低的脱靶毒性，而且具有超高的类过氧化氢酶、类氧化酶和类过氧化物酶等多种酶活性，因此能够产生活性氧物种(ROS)，以有效地破坏 ...