A light cascade-enhanced synergistic PTT/PDT/CDT was achieved by Yang et al. using the cyclen-Cu 2+ complexes, where tumor-derived H 2 S reacted with Cu 2+ to generate CuS for PTT and release Ce6 for PDT. The intracellular hypoxic stress was amplified to trigger AQ4N-associated CDT, resulting in a light cascade-enhanced synergistic PTT/PDT/CDT.

2024年5月25日 · The CuS@Rutin demonstrated the dual functionality of PTT and PDT. When subjected to near-infrared laser irradiation, it exhibited potent bactericidal effects against Escherichia coli and Staphylococcus aureus , effectively regulated ROS levels, and modulated the expression of inflammation-related cytokines, thereby alleviating local inflammation.

2017年9月1日 · Photodynamic therapy (PDT) and photothermal therapy (PTT) have been emerging as attractive and promising methods for tumor treatment in clinical approaches. CuS nanoparticles are effective and cost-effective agents for PTT. Recently, it was observed that CuS nanoparticles are also excellence candidates for PDT.

Photodynamic therapy (PDT) and photothermal therapy (PTT) have been emerging as attractive and promising methods for tumor treatment in clinical approaches. CuS nanoparticles are effective and cost-effective agents for PTT.

2020年7月3日 · Excellent anti-tumor effects have been achieved by synergistic PTT/PDT/immunotherapy. The metastasis of tumors was effectively inhibited by the immune response of CpG. Thus, our proposed work...

2023年12月14日 · As a PTT/PDT combination therapeutic platform, CuS@COF nanosheets possess a porous TP-BDT-based COF shell, and it can sufficiently contact oxygen to provide high singlet oxygen (1 O 2) yield under 505 nm laser irradiation. Upon illumination with a 1064 nm laser, CuS@COF nanosheets can effectively convert the photon energy into thermal energy ...

这里的目标是探索cus纳米颗粒作为ptt和pdt试剂的杀灭机制。 通过简单的湿化学方法，用两亲性聚合物包被，合成CuS纳米颗粒，并在体外和体内检查其对肺腺癌细胞SPC-A-1的治疗潜力使用鼠类癌症模型。

东北大学生命科学与健康学院 分子医学研究所刘弘光教授课题组合成了在808 nm和1275 nm处具有相近吸收值的 聚乙二醇 包裹的硫化铜纳米颗粒（CuS-PEG NPs），以此为平台，对比了808 nm和1275 nm激光在深层组织光热治疗方面的能力。 在对比实验中，1275 nm激光较808 nm激光展现出更高的组织穿透比率，更高的深层组织升温能力以及更有效的深层组织肿瘤杀伤能力。 通过鼠尾静脉注射CuS-PEG NPs后开展的光热治疗实验验证了1275 nm激光应用于光热治疗的可 …

2023年9月15日 · 采用聚多巴胺（PDA）包覆CeO 2 @CuS，并通过叶酸对PDA表面进行修饰，以达到针对肿瘤的靶向作用。 PTT引起的局部热疗可以进一步提高纳米平台的CDT效率，从而产生PTT/CDT协同效应。 该纳米平台具有癌细胞靶向能力，在体外取得了更好的治疗效果。 这项工作为组合多功能治疗平台提供了新策略，并在实际应用中显示出强大的潜力。 Single tumor treatment method usually has some defects, which makes it difficult to achieve good therapeutic effect.

Hollow CuS nanoparticles can achieve photothermal and photodynamic therapy (PDT) in tumor treatment. However, excessive GSH in the tumor cells will consume the reactive oxygen species produced by PDT and reduce the PDT effect.