Catenin alpha 1 (CTNNA1), encoding α-catenin, is involved in several physiological activities, such as adherens junction synthesis and signal transduction. Recent studies have suggested …

CTNNA1, encoding for α-E-catenin, and E-cadherin-partner in the adherens junction complex, has been recently classified as a HDGC predisposing gene. Nevertheless, little is known about …

Mar 28, 2025 · CTNNA1 (Catenin Alpha 1) is a Protein Coding gene. Diseases associated with CTNNA1 include Macular Dystrophy, Patterned, 2 and Diffuse Gastric And Lobular Breast …

αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. [5][6] αE-catenin is highly expressed in cardiac muscle and localizes to …

The CTNNA1 gene is associated with autosomal dominant CTNNA1-related diffuse gastric cancer (PMID: 34425242) and autosomal dominant butterfly-shaped pigmentary macular dystrophy …

study identifies CTNNA1 gene variants as a cause of macular dystrophy, indicates that CTNNA1 is involved in maintaining RPE integrity; The results demonstrate a Fas-mediated apoptotic …

Nov 27, 2024 · Title: Cancer predisposition and germline CTNNA1 variants. Suppression of alpha-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE …

Mar 17, 2023 · This chapter focuses on CTNNA1, the second gene to be acknowledged as a hereditary diffuse gastric cancer (HDGC) predisposing gene. CTNNA1 loss of function was …

Feb 13, 2020 · CTNNA1 is a potential diffuse gastric cancer risk gene, however CTNNA1 testing on multigene panel testing (MGPT) remains unstudied. De-identified data from 151,425 …

Oct 1, 2021 · CTNNA1, encoding for α-E-catenin, and E-cadherin-partner in the adherens junction complex, has been recently classified as a HDGC predisposing gene. Nevertheless, little is …