2023年12月7日 · In this work, we describe the synthesis of sterically attenuated, NHC-based, and pincer-supported cobalt-alkyl and -aryl complexes and their activity for C (sp 2)–H activation resulting in the borylation of nonfluorinated arenes and heteroarenes and, ultimately, meta -selective C (sp 2)–H borylation of fluoroarenes and tri- and difluoromethoxyla...

2021年6月18日 · 近日，印度孟买理工学院的Debarata Maiti等人在Science 上详细地总结了过渡金属催化的芳烃远程（间位或对位）C(s p 2)-H键活化的反应策略，主要分为以下六种：（i）σ键活化辅助（图1C）；（ii）共价键模板导向（图1D）；（iii）非共价键相互作用导向（图1F）；（iv ...

2024年8月30日 · 本综述的目的是描绘 Pd 催化的远端 C(sp 2)–H 和 C(sp 3)–H 功能化反应的最新进展、其机制以及在药物化合物后期功能化中的应用并强调其局限性，从而为进一步的综合调整留下了空间。

2022年8月25日 · 在此基础上，近日刘路教授课题组通过使用金/手性磷酸共催化的策略实现了非活化芳烃的高对位选择性和对映选择性的C(s p 2)-H键官能团化反应（图3）。

4 天之前 · The site-selective functionalization of C(sp2)–H bonds is a powerful strategy for the synthesis of structurally diverse compounds with broad applicability. Here the authors show ruthenium ...

2018年10月24日 · An efficient general method using a clean and transition-metal-free photochemical strategy for the direct Csp 2-H radical difluoromethylation of coumarins with HCF 2 SO 2 Na was developed. The visible-light-promoted strategy proceeds with 5 mol % Eosin Y under mild reaction conditions and showed excellent functional group compatibility.

2019年10月18日 · The present protocol provides an efficient Cu (0)/Selectfluor-system catalyzed CDC annulation of 2-aryloxybenzaldehydes to deliver xanthone derivatives involving an in situ generated HOCu (II)X (X = F or BF 4) as a key catalytic species.

2021年11月5日 · We reveal here a novel and efficient transition-metal-free C (sp 2)–H oxidative difluoromethylation of heterocycle. It uses stable and nontoxic NaSO2 CF 2H as difluoromethyl source and potassium persulfate as oxidant without the need for metal catalyst.

2024年2月21日 · Among the key techniques, direct functionalization of Csp 2 –H is a powerful tool, enabling the construction of new Csp 2 –C bonds in an economical and atomic manner. Herein we present and summarize the large plethora of direct Csp 2 –H functionalization methods that enables scaffold diversification of simple, unprotected phenols, leading ...

近日， 华东师范大学 刘路教授课题组开发了一种金／手性磷酸共催化体系实现了烷基芳烃对位选择性的不对称C(sp2)-H键官能团化，相关成果在线发表在Angew. Chem. Int. Ed.（DOI: 10.1002/anie.202208874）。 图1. 芳香化合物的选择性C(sp2)-H官能团化反应（来 …