The selective CRH1 receptor (CRH1R) antagonist antalarmin (0, 10, 20 mg/kg, i.p.) was tested on alcohol consumption. Results: Intermittent access to 20% alcohol led non-selected Wistar rats …

Corticotropin-releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF1, with the latter (CRF 1) now being the IUPHAR -recommended name. [4] . In humans, CRF 1 is …

2025年3月30日 · CRHR1 (Corticotropin Releasing Hormone Receptor 1) is a Protein Coding gene. Diseases associated with CRHR1 include Anxiety and Depressive Disorder. Among its …

该基因编码一种 G 蛋白偶联受体，该受体结合促肾上腺皮质激素释放激素家族的神经肽，这些激素家族是下丘脑-垂体-肾上腺通路的主要调节因子。 编码的蛋白质对于激活调节多种生理过程 ( …

促肾上腺皮质激素释放激素 (CRH) 通过表达在VTA上多巴胺神经元的CRH 受体 1 (CRHR1) 调控应激相关的行为反应。 此外，敲除VTA脑区多巴胺神经元的CRHR1可促进焦虑样行为，敲除该 …

Results show that CRHR1 is expressed in human articular chondrocytes (AC) and binds to UCN1 to promote survival of AC cells in the absence of pro-apoptotic stimuli. Patients were different …

2015年9月9日 · CRHR1 is a G protein-coupled receptor (GPCR) of the B1 family and preferentially signals via Gsα, resulting in the activation of the adenylyl cyclase/protein kinase …

2012年1月1日 · Pharmacological blockade of CRH1R reduced alcohol drinking when sustained high levels of intake were achieved suggesting that the CRH system plays a key role when …

Enhanced CRH1R expression may be involved in adrenocortical tumorigenesis. Corticotropin-releasing hormone (CRH) is not only the principal regulator of the central hypothalamic …

2023年1月1日 · We review and describe cellular components and molecular mechanisms involved in CRH system signaling through G protein-coupled receptors (GPCRs) CRHR1 and …