uolar protein carboxypeptidase Y (CPY). Mutations in VPSlO result in the selective missorting and secretion of CPY; all other vacuolar proteins tested are delivered to the vacuole in vpsf0 mutants. Chemical cross-linking studies demonstrate that VpslOp and the Golgi-modi-

Enzyme replacement therapy (ERT) for lysosomal storage diseases exploits this M6P-MPR-dependent endocytosis to deliver recombinant enzymes to lysosomes. This review discusses various engineering and application technologies using M6P’s lysosomal targeting.

甘露糖-6-磷酸 （英語： Mannose-6-phosphate，縮寫 M6P）是一个在 免疫系统 中与 凝集素 结合的分子，M6P可由 磷酸甘露糖异构酶 （英语：mannose phosphate isomerase） 转化为 果糖-6-磷酸。

2014年5月16日 · There are two well-described sorting principles at the TGN. This is the (A) receptor-mediated sorting of lysosomal hydrolases via M6P (Mannose-6-Phosphate) and the M6P receptor (M6PR) to the lysosome via endosomes, in clathrin-coated vesicles. Another class of soluble proteins is sorted via sortilin and clathrin to endosomes, eventually ...

2024年12月19日 · m6p标记纳米载体可用于将药物特异性靶向溶酶体，通过溶酶体降解释放药物。 用于靶向肿瘤细胞中的溶酶体，提高药物的效率。 溶酶体功能异常与肿瘤进展：

2012年11月1日 · The majority of the enzymes leave the TGN after modification with mannose-6-phosphate (M6P) residues, which are specifically recognized by M6P receptors (MPRs), ensuring their transport to the endosomal/lysosomal system.

2012年4月1日 · The explanation of how are the lysosomal enzymes accurately recognized and selected over many other proteins in the trans -Golgi network relies on being tagged with a unique marker: the mannose-6-phosphate (M6P) group, which is added exclusively to the N-linked oligosaccharides of lysosomal soluble hydrolases, as they pass through the cis -Golgi...

2018年6月7日 · We constructed glyco-engineered yeast harboring a high content of mannosylphosphorylated glycans, which can be converted to M6P glycans by uncapping of the outer mannose residue. In this study,...

This review synthesizes the current knowledge on each of the major proteins involved in the M6P-dependent pathway. Impairments in this pathway will also be addressed, highlighting the lysosomal storage disorders associated to GlcNAc-1-phosphotransferase loss of function: mucolipidosis type II and III.

甘露糖-6-磷酸（英语：Mannose-6-phosphate，M6P）是一个在 免疫系统 中与 凝集素 结合的分子，M6P可由 磷酸甘露糖异构酶 转化为 果糖-6-磷酸。 若非注明，所有数据均出自一般条件（25 ℃，100 kPa）下。 甘露糖-6-磷酸（英语：Mannose-6-phosphate，M6P）是一个在免疫系统中与凝集素结合的分子，M6P可由磷酸甘露糖异构酶转化为果糖-6-磷酸。