由该基因编码的蛋白质是肉碱/胆碱乙酰转移酶家族的成员，是肌肉线粒体中长链脂肪酸 β-氧化途径的速率控制酶。 这种酶是长链脂肪酰辅酶 A 从细胞质净运输到线粒体所必需的。 已发现该基因编码不同异构体的多个转录变体，通读转录本从包括该基因外显子的上游位点表达。 [RefSeq 提 …

为了确定FAO在体内调节CM增殖和生长的作用，研究团队构建了αMHC-Cre pos/+；Cpt1b fl/fl小鼠（以下简称Cpt1b cKO），其中Cpt1b基因在胚胎阶段的CM中特异性失活。

2025年3月30日 · CPT1B (Carnitine Palmitoyltransferase 1B) is a Protein Coding gene. Diseases associated with CPT1B include Carnitine Palmitoyltransferase I Deficiency and Chanarin-Dorfman Syndrome. Among its related pathways are AMP-activated …

2023年9月27日 · Inhibition of the fatty acid oxidation metabolic pathway through inactivation of Cpt1b enhances cardiomyocyte survival and proliferation and allows heart regeneration in adult mice.

2024年12月30日 · CPT1B，全称为肉碱棕榈酰转移酶1B（carnitine palmitoyltransferase 1B），是一种位于22号染色体q13.33区域的基因。 这个基因编码的蛋白质也被称为 M-CPT1 或 CPT1-M ，在人体中起着至关重要的作用。

CPT1B, a metabolic molecule, is also an independent risk factor in CN-AML. Low carnitine palmitoyltransferase 1 activity is a risk factor for narcolepsy type 1 and other hypersomnia. Resting skeletal muscle PNPLA2 (ATGL) and CPT1B are associated with peak fat oxidation rates in men and women but do not explain observed sex differences.

2025年2月8日 · Title: Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer. Low expression of CPT1B in high-grade urinary bladder cancer was associated with low fatty acid oxidation and low acyl carnitine levels.

The muscle isoform, CPT1b, is the predominant isoform expressed in the heart. It has been suggested that inhibiting CPT1 activity by specific CPT1 inhibitors exerts protective effects

为了确定FAO在体内调节CM增殖和生长的作用，研究人员构建了Cpt1b敲除（Cpt1b cKO）小鼠，其中Cpt1b基因在胚胎阶段的CM中特异性失活。 观察发现，与对照小鼠相比， Cpt1b cKO 小鼠的体重(BW)、心脏重量(HW)、HW/BW比值和心脏形态未发生变化。

2025年2月8日 · Cardiac CPT-1b suppression protects against the aggravation of cardiac morphology and function associated with HFD feeding. CPT-1b represents a potential therapeutic target for the treatment of cardiac dysfunction related to …