CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine triphosphate deoxynucleotide ("C") followed by a guanine triphosphate deoxynucleotide ("G").

InvivoGen offers high-quality CpG ODNs that are functionally tested and guaranteed endotoxin-free to avoid non-specific immune stimulation. The most widely referenced of them are ODN2006, ODN1826 and ODN2216.

Three major classes of stimulatory CpG ODNs have been identified based on structural characteristics and activity on human peripheral blood mononuclear cells (PBMCs), in particular B cells and plasmacytoid dendritic cells (pDCs). These three classes are Class A (Type D), Class B (Type K) and Class C.

CpG oligodeoxynucleotides (CpG-ODN) are short single-stranded DNA molecules composed of cytosine and guanine triphosphate deoxynucleotides linked with a phosphodiester backbone. You might find these chapters and articles relevant to this topic. The impact of tumor and gut microbiotas on cancer therapy: Beneficial or detrimental?

This chapter reviews recent progress in understanding the mechanism of action of CpG ODN and provides an overview of human clinical trial results using CpG ODN to improve vaccines for the prevention/treatment of cancer, allergy, and infectious disease.

2013年5月14日 · Here we show that at high doses, CpG-rich oligodeoxynucleotides promote an opposite, tolerogenic response in mouse plasmacytoid dendritic cells in vivo and in a human in vitro model.

Preclinical and early clinical trials indicate synthetic oligodeoxynucleotides containing unmethylated CG dinucleotides (CpG ODN) have potent immunostimulatory effects and can enhance the anti-cancer activity of a variety of cancer treatments. ...

2004年4月1日 · Human immune cells are stimulated by three structurally distinct classes of CpG oligodeoxynucleotide (ODN). Different types of immune response are triggered by each class of ODN. The innate...

CpG oligodeoxynucleotides (CpG ODNs), the artificial versions of unmethylated CpG motifs that were originally discovered in bacterial DNA, are demonstrated not only as potent immunoadjuvants but also as anticancer agents by triggering toll-like receptor 9 (TLR9) activation in immune cells.

ODN 2006 (ODN 7909) is a Class B CpG oligonucleotide (ODN) with a preference for the human Toll-like receptor 9 (TLR9). It is a short synthetic single-stranded DNA molecule containing unmethylated CpG dinucleotides (CpG motifs).