Let's start with a simple compound, ethyl acetate. The 1 H NMR spectrum is not very complicated. In homonuclear correlation spectroscopy (COSY), we can look for hydrogens that are coupled to each other. In ethyl acetate, it's pretty clear where they are.

关联性磁振频谱（Correlation spectroscopy, COSY）是二维核磁共振（NMR）频谱学中的一种技术，其他二维NMR技术包括有J频谱（J-spectroscopy）、交换谱（Exchange spectroscopy, EXSY）及核欧佛豪瑟效应频谱（Nuclear Overhauser effect spectroscopy, NOESY）。

核磁共振技术（nmr）作为结构鉴定最权威的方法，深受化学家们的衷爱。 其中， 1H NMR，13C NMR，DEPT135°，1H-1H COSY，HSQC和HMBC是实验室最常见的谱图，仅通过氢谱和碳谱，我们通常可以很好地确证简单化合物的结…

cosy一般反映的是邻碳氢的偶合关系，从而可知同一自旋体系里质子之间的偶合关系，是归属谱线、推导结构强有力的工具。 谱图特征是对角线上的峰对应一维1H谱，对角线外的交叉峰在F1和F2，域的σ值对应相偶合核的化学位移，提供通过三键偶合的IH-H相关信息。

Gained Information: The COrrelation SpectroscopY (COSY) NMR experiment is a proton-detected 2D experiment that shows you protons that are J-coupled. You will see your 1H spectrum on both axis, and you will see a cross peak for any protons that are J-coupled.

关联性磁振频谱（Correlation spectroscopy, COSY）是二维核磁共振（NMR）频谱学中的一种技术，其他二维NMR技术包括有J频谱（J-spectroscopy）、交换谱（Exchange spectroscopy, EXSY）及核欧佛豪瑟效应频谱（Nuclear Overhauser effect spectroscopy, NOESY）。

COSY (Correlated Spectroscopy) was one of the first multidimensional experiments. Cross peaks in COSY are between protons that are coupled. COSY tells you "what proton is coupled to what proton." Protons that are two, three, or sometimes four bonds apart may show cross peaks. The magnitude of the couplings affects the peak intensity.

2024年12月18日 · Correlation Spectroscopy (COSY) The most basic form of 2-D NMR is the COSY (COrrelation SpectroscopY) experiment. This experiment looks at 1 H coupling to 1 H through bonds typically 3 bonds away. It relies on the J-coupling to provide spin-spin correlation to indicate which protons are close to each other on the cross peak.

There are many variants on the COSY pulse sequence. The most popular one in our laboratory is the gradient enhanced double quantum coherence (DQF-COSY) version. The ratio of gradient strengths is usually set to two to yield all COSY signals but may be set to three to yield only those correlations involving three protons, e.g., CH-CH 2.

2025年2月25日 · COrrelation SpectroscopY (COSY) is one of the most common 2D NMR experiments. Why? Because, like most 2D experiments, it helps deconvolute complex data. A COSY experiment can be useful for assigning resonances in a 1D spectrum because it shows you which proton spins that are coupled to each other.