正腎上腺素的分解，comt以綠色盒子表示。 [1]兒茶酚-o-甲基轉移酶（comt; ec 2.1.1.6）是分解兒茶酚胺（如多巴胺、腎上腺素和去甲腎上腺素）的幾種酶之一。在人體，兒茶酚-o-甲基轉移酶由comt基因編碼 [2] 。 鑒於在一些疾病中兒茶酚胺的調節受損，數種藥物以comt為標靶，調整其活性來控制兒茶酚胺的 ...

2023年11月30日 · 3. It's also key to eat foods that remove excess catachol estrogens from the body and avoid foods and bath products that mimic estrogen.. Excess estrogen slows COMT and COMT is largely responsible ...

Catechol-O-methyltransferase is involved in the inactivation of the catecholamine neurotransmitters (dopamine, epinephrine, and norepinephrine).The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine (SAM). Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT.

1. 概述. 儿茶酚-O-甲基转移酶（Catechol-O-Methyltransferase, COMT）是一种参与儿茶酚胺类物质代谢的酶，主要负责将儿茶酚胺类神经递质（如多巴胺、去甲肾上腺素和肾上腺素）以及儿茶酚雌激素进行甲基化，生成相应的甲基化产物。

儿茶酚-o-甲基转移酶： 儿茶酚-o-甲基转移酶催化甲基从 s-腺苷甲硫氨酸转移到儿茶酚胺，包括神经递质多巴胺、肾上腺素和去甲肾上腺素。这种 o-甲基化导致儿茶酚胺递质的主要降解途径之一。除了在内源性物质的代谢中发挥作用外，comt 在用于治疗高血压、哮喘和帕金森病的儿茶酚类药物 …

Other disorders. Variations in the COMT gene also may be associated with mental illness in people without 22q11.2 deletion syndrome. Researchers have looked extensively at the potential connection between changes in the COMT gene and the risk of developing schizophrenia. Most studies have focused on the effects of a particular common variation (polymorphism) in catechol-O-methyltransferase.

2025年3月28日 · COMT (Catechol-O-Methyltransferase) is a Protein Coding gene. Diseases associated with COMT include Schizophrenia and Panic Disorder 1.Among its related pathways are Metapathway biotransformation Phase I and II and Neurotransmitter clearance.Gene Ontology (GO) annotations related to this gene include magnesium ion binding and catechol O-methyltransferase activity.

中文名称 儿茶酚-O-甲基转移酶 英文名称 catechol-Omethyl transferase;COMT 定 义 编号：EC 2.1.1.6。催化S-腺苷酰甲硫氨酸的甲基转移至儿茶酚或儿茶酚胺的苯环3-位羟基上的酶。

2024年1月1日 · Catechol-O-methyltransferase (COMT) is a magnesium-dependent enzyme responsible for the catalytic O-methylation reaction of endogenous catecholamines and neurotransmitters.It is also involved in the metabolic process of various hormones and drugs incorporating catecholic structures. COMT has become an attractive biological target in the central nervous system (CNS) disorders associated with ...

2017年4月30日 · Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols.Although its classical function has been established for more than five decades, an ever expanding COMT role in other pathways and diseases has become a subject of active study in ...