2023年6月6日 · The nucleus of the human genome is partitioned into distinct spatial compartments, such that stretches of active chromatin tend to lie in one compartment, called …

A compartments： 开放的染色质，表达活跃，基因丰富，具有较高的GC含量，包含用于主动转录的组蛋白标记，通常位于细胞核的内部。 B compartments： 关闭的染色质，表达不活跃，基 …

2015年8月28日 · These compartments are cell-type specific and are associated with open and closed chromatin. We show that A/B compartments can reliably be estimated using epigenetic …

2015年2月18日 · From the haplotype-resolved A and B compartment patterns across the p1 and p2 alleles in each lineage, we found that homologous chromosomes have highly similar A/B …

2024年10月1日 · In this review, we focus on the A/B compartments, discuss their close relationship to DNA replication timing (RT), and introduce recent findings on the features of …

Each chromosome is made up of both euchromatin or active (A, red) and heterochromatin or inactive (B, blue) chromatin which spatially cluster to form separate compartments within the …

2021年5月10日 · At a broad scale, chromatin segregates into two major compartments, one preferentially localized at the core of the nucleus and exhibiting high transcriptional activity (A …

2024年5月17日 · We formulate the A/B compartment prediction as a binary classification task with classes y ∈ {0, 1}, corresponding to whether a chromosome region is in A (active) …

2023年6月15日 · Chromosome conformation capture outlined genome segregation into large scale A and B compartments corresponding mainly to transcriptionally active and repressive …

2025年2月13日 · Notably, chromatin regions exhibiting the greatest structural variations between clusters (regions I–IV) also show the largest shifts in A/B compartment eigenvalues (Fig. 5A). …