A coiled coil is a structural motif in proteins in which 2–7 [1] alpha-helices are coiled together like the strands of a rope. (Dimers and trimers are the most common types.) They have been found in roughly 5-10% of proteins and have a variety of functions. [2] . They are one of the most widespread motifs found in protein-protein interactions.

Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains of some proteins are almost invariant in sequence and length, betraying a structural and functional role for amino acids along the entire length of the ...

In this review, I describe recent advances in the field of protein nanotechnology, with a focus on programming assembly of protein nanostructures using coiled-coil modules.

2005年1月1日 · Although our present understanding of coiled-coil folding and assembly is not complete, through numerous bioinformatics and experimental studies there are now sufficient rules to allow confident design attempts of naturally observed and even novel coiled-coil motifs.

Structurally, coiled coils comprise two or more α-helices in a parallel or antiparallel orientation that are wound around each other to form a regular supercoiled bundle.

2008年10月8日 · CC+ has two interfaces: (i) a form-based ‘Dynamic Interface’ for customizable searching and (ii) a graphical interface for a ‘Periodic Table of Coiled-coil Structures’. The CC+ relational database comprises tables of coiled-coil data organized according distinct aspects of coiled-coil structure.

2017年2月1日 · In this table we captured two-, three-, and four-helical coiled coils in parallel and antiparallel orientation, all showing rod-shaped structures of various lengths, and left-handed supercoils built of heptads or closely related periodicities.