Vitamin B 12 boasts a complex façade yet mediates an abundance of intricate chemistries that ultimately derive from the properties of a central cobalt ion. This essential dietary component …

2021年1月1日 · Vitamin B 12, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that represents one of the most complex small molecules made by nature. In …

2019年8月17日 · Replacing the central cobalt ion of vitamin B 12 by other metals has been a long-held aspiration within the B 12-field. Herein, we describe the synthesis from …

2020年10月12日 · Cobalt, as a trace element, is essential for rumen microorganisms for the formation of vitamin B12. In the metabolism of mammals, vitamin B12 is an essential part of …

This review has outlined the enormous impact of structural studies on the development of B 12 chemistry and biochemistry and, more recently, to B 12 enzymology. A lot of experimental and …

2022年7月21日 · Vitamin B 12 mediates the formation of radicals from electrophilic molecules including organic halides, diazo reagents, thioesters, and strained molecules. These, however, …

2021年1月1日 · Vitamin B12, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that represents one of the most complex small molecules made by nature. In …

Cobalt has its important biological role as metal center of vitamin B 12 and of its cofactor variants. The natural B 12 derivatives are remarkably complex cobalt-corrins and belong to the larger …

2011年1月1日 · Vitamin B12, the “antipernicious anaemia factor”, is a crystallisable cobalt-complex, which belongs to a group of unique “complete” corrinoids, named cobalamins (Cbl).

2020年10月12日 · We review the role of cobalt and vitamin B12 in animals, especially in ruminants. Vitamin B12 is an essential part of the enzyme systems involved in multiple …