CLOCK Gene - GeneCards | CLOCK Protein | CLOCK …
2024年10月1日 · CLOCK (Clock Circadian Regulator) is a Protein Coding gene. Diseases associated with CLOCK include Delayed Sleep Phase Disorder and Seasonal Affective Disorder. Among its related pathways are Circadian Clock and Chromatin organization.
The role of clock genes in sleep, stress and memory
2021年9月1日 · Indeed, recent data suggests that clock genes outside the SCN are involved in fundamental brain processes such as sleep/wakefulness, stress and memory. The role of clock genes in these brain processes are complex and divers, influencing many molecular pathways and phenotypes.
The role of clock genes in sleep, stress and memory - PMC
Clock genes serve as the basis of an intracellular timekeeping system, present throughout the body, which generates approximately 24-hour rhythms in physiology and behavior. Transcripts and protein products of these genes show near-24-hour oscillations in expression [18,74,79].
Genetics of Circadian Rhythms - PMC
Mutations in core clock genes are involved in the pathogenesis of some familial circadian rhythm sleep-wake disorders. Beyond these core clock genes, rhythmic transcription programs regulate gene expression and gene activity throughout the genome.
9575 - Gene ResultCLOCK clock circadian regulator
CLOCK Genetic Variations Are Associated With Age-Related Changes in Sleep Duration and Brain Volume. Circadian protein CLOCK modulates regulatory B cell functions of nurses engaging day-night shift rotation.
Mutation of the Human Circadian Clock Gene - Cell Press
2017年4月6日 · Here, we report a hereditary form of DSPD associated with a dominant coding variation in the core circadian clock gene CRY1, which creates a transcriptional inhibitor with enhanced affinity for circadian activator proteins Clock and Bmal1.
Genetics of the human circadian clock and sleep homeostat …
2019年8月10日 · Genetic variations have been identified that lead to a short sleep phenotype in which individuals sleep only 4–6.5 h nightly. Negative health consequences have been identified when...
Clock Genes - SpringerLink
2024年1月1日 · Clock genes are components of the circadian clock comparable to the cogwheels of a mechanical watch. They interact with each other in an intricate manner generating oscillations of gene expression.
Transcriptional architecture of the mammalian circadian clock
2016年12月19日 · Circadian CLOCK–BMAL1 gene targets are directly linked to metabolism, immune function, cell proliferation, cancer and signalling. Circadian clocks are endogenous oscillators that control...
CLOCK:BMAL1 is a pioneer-like transcription factor - PMC
Circadian gene expression is generated by a set of core clock genes, which interact in transcriptional feedback loops. In mammals, they include the two master heterodimeric transcription factors CLOCK and BMAL1.
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