The name claudin comes from Latin word claudere ("to close"), suggesting the barrier role of these proteins.

Claudin-1是一种新型靶点，具有独特的作用机制，在肝纤维化和纤维化驱动型肝胆癌的病理中发挥关键作用。 Claudin1靶向药物目前有ALE-F02处于1期临床研究、ALE-C04处于临床前研究。

Claudin家族. Claudins是一类存在于上皮和内皮中的整合素膜蛋白，是紧密连接结构和功能的骨架蛋白，位于相邻细胞间隙顶侧，与其他结构蛋白和信号蛋白协同作用，主要功能有细胞间黏附、维持细胞稳态、调节细胞通透性、调节细胞增殖及分化。

2024年9月9日 · 用于 claudin 靶向治疗的单克隆抗体在初始肿瘤学临床试验中显示出前景 （5）。只要蛋白质可及，抗体就以高亲和力和高特异性与靶蛋白结合。针对 claudin 家族的抗体在肿瘤学、再生医学、炎症性疾病和病毒感染方面具有潜在兴趣 （18）。

目前认为，跨膜蛋白中起主要作用的是Occludin和Claudin，尤其以Claudin的作用最为重要，这是形成紧密连接功能的主要蛋白 [1]。 Claudin主要作用是维持细胞间的物理屏障功能及细胞极性。

2018年10月25日 · Claudins are cell–cell adhesion molecules located at the tight junctions (TJs) between cells in epithelial cell sheets. The claudin family in mammals consists of 27 four-transmembrane domain proteins.

2024年3月19日 · In this Review, we highlight the biological rationale and explore the clinical activity of therapies that target claudin 18.2 in patients with advanced-stage gastric cancer and explore the ...

Claudins are a family of nearly two dozen transmembrane proteins that are a key part of the tight junction barrier that regulates solute movement across polarized epithelia. Claudin family members interact with each other, as well as with other ...

Claudin proteins are a class of transmembrane proteins involved in the formation of tight junctions (TJ), characterized by four transmembrane domains and two extracellular loops. Abnormal Claudin expression is closely associated with cancers and inflammatory bowel disease.

2019年1月29日 · At the blood-brain barrier, claudin-5 is the most enriched tight junction protein and its dysfunction has been implicated in neurodegenerative disorders such as Alzheimer's disease, neuroinflammatory disorders such as multiple sclerosis as well as psychiatric disorders including depression and schizophrenia.