- In biology, the chromosome scaffold is the backbone that supports the structure of the chromosomes.了解详细信息：In biology, the chromosome scaffold is the backbone that supports the structure of the chromosomes.en.wikipedia.org/wiki/Chromosome_scaffoldThe chromosome scaffold is biochemically defined as the insoluble protein fraction of a mitotic chromosome after the extraction of histones and DNA digestion [24,25].www.sciencedirect.com/topics/biochemistry-geneti…
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In biology, the chromosome scaffold is the backbone that supports the structure of the chromosomes. It is composed of a group of non-histone proteins that are essential in the structure and maintenance of eukaryotic chromosomes throughout the cell cycle. These scaffold proteins are responsible for the … 展开
In the late 1970s, Ulrich K. Laemmli and colleagues discovered a backbone structure in eukaryotic chromosomes after they depleted the 展开
In eukaryotic organisms, the DNA of each cell is organized into separated chromosomes, which are composed of chromatin, a … 展开
CC-BY-SA 许可证中的维基百科文本 纯二代测序从头组装基因组(基础版） - 知乎专栏
- 基因组组装一般分为三个层次，contig, scaffold和chromosomes. contig表示从大规模测序得到的 …
目前基于二代测序的组装存在挑战： - •全基因组测序得到的短读远远小于原来的分子长度
•高通量测序得到海量数据会增加组装的计算复杂性，消耗更高的计算资源
- 基因组组装一般分为三个层次，contig, scaffold和chromosomes. contig表示从大规模测序得到的 …
经典：基因组测序数据从头拼接或组装算法的原理 - 知乎
Scaffold protein - Wikipedia
12 行 · Chromosome scaffold has important role to hold the chromatin into compact …
Chromosome Scaffold is a Double-Stranded Assembly of Scaffold …
2015年7月1日 · We therefore propose a new structural model of the chromosome scaffold that includes twisted double strands, consistent with the physical properties of chromosomal …
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Chromosome Scaffold - an overview | ScienceDirect Topics
The chromosome scaffold consists of a group of non-histone proteins that interact with the DNA to form the structural backbone of the chromatid (Paulson and Laemmli, 1977). This scaffold is a …
Chromosome-level scaffolding of haplotype-resolved assemblies …
2024年8月5日 · In this Article, we introduce HapHiC, a Hi-C-based scaffolding tool that enables allele-aware chromosome scaffolding of autopolyploid assemblies without reference genomes.
Building a case for the chromosome scaffold - PMC - National …
2005年12月5日 · Now, the scaffold is envisioned as a protein core or network that regulates the higher-order structure of chromosomes—possibly by binding stretches of DNA called scaffold …
Chromosome-scale scaffolding of de novo genome …
2013年12月1日 · We demonstrate the approach by combining shotgun fragment and short jump mate-pair sequences with Hi-C data to generate chromosome-scale de novo assemblies of the human, mouse and Drosophila ...
Mitotic chromosome scaffold structure: New approaches to an old …
2002年12月2日 · Striking images of extended DNA “halos” surrounding a linear protein core, roughly the shape of the native chromosome, led to a simple model in which a central protein …
