Chiral alcohols form a versatile class of chiral synthons, since they can be incorporated into the API structures directly as esters or ethers. They can be starting materials for the formation of amines, amides, thiols, thioethers.

2024年10月1日 · Biocatalysis offers high selectivity in chiral alcohol synthesis, enabling the formation of enantiomerically pure molecules. Advances in bioprocess engineering, reactor design, and enzyme immobilization enable scalable biocatalytic production of chiral alcohols.

We offer a wide range of chiral alcohols to meet their ever-growing demand. These useful reagents may serve both as starting materials in the synthesis of single-stereoisomer drugs or intermediates, or as powerful resolving agents.

2022年12月13日 · Enantioselective synthesis of chiral alcohols through asymmetric addition of water across an unactivated alkene is a highly sought-after transformation and a big challenge in catalysis. Herein we report the identification and directed evolution of a fatty acid hydratase from Marinitoga hydrogenitolerans for the highly enantioselective hydration ...

2024年8月1日 · Chiral alcohols are essential building blocks of numerous pharmaceuticals and fine chemicals. Aldo-keto reductases (AKRs) constitute a superfamily of oxidoreductases that catalyze the reduction of aldehydes and ketones to their …

2024年1月15日 · A cytochrome P450 monooxygenase called P450 PL2 was developed to enable chiral tertiary alcohols by the benzylic C H bonds asymmetric hydroxylation of the racemic tertiary carbon substrates. This P450-catalyzed protocol provides various chiral tertiary alcohols with unexpectedly functional group tolerance and excellent enantioselectivities (up ...

6 天之前 · Aliphatic chiral secondary alcohols are important chiral intermediates widely used in the synthesis of drugs and fine chemicals. The whole cells of recombinant E. coli co-expressing alcohol dehydrogenase and glucose dehydrogenase were used to catalyze the asymmetric reduction of three fatty ketones without the addition of exogenous cofactors. The reaction medium and reaction conditions were ...

2009年3月13日 · Enantiodivergent conversion of chiral secondary alcohol to chiral tertiary alcohol

Chiral alcohols form a versatile class of chiral synthons, since they can be incorporated into the API structures directly as esters or ethers. They can be starting materials for the formation of amines, amides, thiols, thioethers.

2016年2月1日 · Remarkable progress in the enantioselective addition of Grignard reagents to carbonyl compounds has been made over the past decade. This enantioselective transformation now allows the use of these challenging reactive nucleophiles for the formation of chiral alcohols using catalytic amounts of chiral ligands.