The chiral pool is a "collection of abundant enantiopure building blocks provided by nature" used in synthesis. [1][2] In other words, a chiral pool would be a large quantity of common organic enantiomers. Contributors to the chiral pool are amino acids, sugars, and terpenes. Their use improves the efficiency of total synthesis.

Chiral Pool Adapted and expanded from: Wyatt and Warren, “Organic Synthesis,” Wiley, 2007, Ch. 23: The Chiral Pool

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For a review of the use of amino acid derivatives in organic synthesis see: Chem. Rev., 1989, 89, 149-164. Chiral Pool Molecules is shared under a CC BY-NC-SA 4.0 license and was …

Chiral pool terpene syntheses are influenced by three main factors: (i) the current availability of the starting terpene building blocks, (ii) the current state of the art in synthetic methodology, and (iii) the creativity of the practitioner.

Chiral pool method: The method using an easily available chiral compound as a starting material like an amino acid or sugar.

2021年10月28日 · Chiral pools have been commonly utilized as inexpensive and versatile building blocks in organic synthesis. In this account, we provide an overview of our recent synthetic efforts toward polycyclic natural products using chiral natural small …

In most cases, the easiest way to decide whether a molecule is chiral or achiral is to look for one or more stereocenters - with a few rare exceptions, the general rule is that molecules with at least one stereocenter are chiral, and molecules with no stereocenters are achiral.

2016年6月15日 · The applications of the chiral pool in asymmetric synthesis can be categorized prudently as chiral sources, devices, and inducers. This review specifically examines recent advances in substrate-controlled asymmetric reactions induced by the chirality of α-amino acid templates in natural product synthesis research and related areas.

Chiral reagents can form energetically different TS’s when approaching prochiral faces or groups on a molecule, and thus perform enantioselective reactions DIRECTLY on an achiral starting material.