A local inflammatory lesion (chagoma) may occur after the entry of the parasite in acute Chagas’ disease. The chagoma contains mononuclear cell infiltrate, interstitial oedema, and intracellular amastigotes. Biopsy samples from affected lymph nodes also demonstrate hyperplasia and amastigotes in reticular cells.

Chagas disease is caused by an infection with a blood parasite called Trypanosoma cruzi. Chagas disease is incurable. Those who have Chagas disease are usually symptom-free. Some people who have been infected for a long time may develop symptoms of heart failure, trouble swallowing, or trouble moving the bowels.

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Some patients with acute Chagas disease have signs at the portal of parasite entry. Inflammation and swelling at the site of inoculation through the skin is known as a chagoma; parasites can sometimes be demonstrated in the lesion. Chagomas typically present on the face or extremities.

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Chagoma of the right orbit. This media comes from the Centres for Disease Control and Prevention's Public Health Image Library (PHIL), with identification number #2617. Provider: …

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American trypanosomiasis, commonly known as Chagas disease, is a systemic infection caused by the zoonotic protozoan parasite Trypanosoma cruzi. Who gets American trypanosomiasis? American trypanosomiasis is endemic in the southern half of the United States, and 21 countries in South and Central America.