2013年8月9日 · CGRP restored the level of Bcl-2/Bax, which was abolished by CGRP 8-37. Current study suggests that norepinephrine inhibits synthesis of Bcl-2 and increases Bax and apoptosis of cardiomyocytes. CGRP restores the ratio of Bcl-2/Bax and attenuates the apoptosis induced by NE, via specific CGRP receptor. Previous Calcitonin gene related peptide CGRP

CGRP elevated the amount of Cleaved-caspase 3 and Bax and reduced the amount of Bcl-2 in human NP cells, which was a potent evidence that CGRP could induce human NP cell apoptosis in vitro.

Clinical and biochemical studies have suggested that calcitonin gene-related peptide (CGRP) is involved in vitiligo skin. The present study was designed to investigate the effect of CGRP on epidermal melanocytes.

Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide, which is primarily localized to C and Aδ sensory fibers. These fibers display a wide innervation throughout the body, with extensive perivascular localization, and have a dual role in sensory (nociceptive) and efferent (effector) function (261, 339).

2024年10月30日 · We analyze the current literature on CGRP’s functions in cerebrovascular regulation, edema formation, neuroinflammation, and neuroprotection. CGRP acts as a potent vasodilator and plays a crucial role in trigeminovascular activation during migraine attacks.

新近发现,辣椒素通过激动内皮细胞上的VR1受体能长时程的上调内皮源性CGRP的表达,VR1受体阻断剂caspazepine可以取消此作用.本研究利用培养的内皮细胞探讨以下几个问题: (1) AngⅡ是否能调节内皮源性CGRP合成与释放; (2) CGRP是否具有抗AngⅡ诱导的内皮细胞凋亡的作用 ...

2018年11月14日 · CGRP inhibited serum deprivation (SD)-induced apoptosis in EPCs after 24 and 48 h and downregulated the expression of apoptosis-related genes, including caspase-3, caspase-8, caspase-9 and Bax. Phosphorylated (p-)ERK1/2, p-p38 and p-JNK protein levels in EPCs treated with CGRP were significantly lower than those in untreated EPCs.

2013年8月9日 · Current study suggests that norepinephrine inhibits synthesis of Bcl-2 and increases Bax and apoptosis of cardiomyocytes. CGRP restores the ratio of Bcl-2/Bax and attenuates the apoptosis induced by NE, via specific CGRP receptor.

2018年6月15日 · The main purpose of this study was to compare in vitro pharmacological properties of human αCGRP (CGRP) and a recently discovered metabolically stable CGRP analogue, SAX, in isolated rat and human artery segments.

2023年7月10日 · Galcanezumab binds to human CGRP with high affinity and prevents CGRP-induced receptor activation. Galcanezumab also inhibits capsaicin-induced vasodilation, a CGRP-induced, concentration-dependent, long-lasting relaxation of human coronary arteries.