Regulation of cGAS–STING signalling and its diversity of cellular ...
2025年1月7日 · In this Review, we describe recent insights from structural studies that have helped to elucidate the molecular mechanisms of the cGAS–STING signalling cascade and we …
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
2021年4月30日 · Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze …
Molecular mechanisms and cellular functions of cGAS–STING ... - Nature
2020年5月18日 · Here, we review the molecular mechanisms and cellular functions underlying cGAS–STING activation and signalling, particularly highlighting the newly emerging diversity of …
Regulation of cGAS-STING signalling and its diversity of cellular ...
2025年1月7日 · In this Review, we describe recent insights from structural studies that have helped to elucidate the molecular mechanisms of the cGAS-STING signalling cascade and we …
The cGAS‒STING pathway in cancer immunity: mechanisms
2 天之前 · Innate immunity represents the body's first line of defense, effectively countering the invasion of external pathogens. Recent studies have highlighted the crucial role of innate …
Targeting cGAS-STING pathway for reprogramming tumor …
2025年3月12日 · The cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) signaling pathway plays a crucial role in activating innate and specific immunity in anti-tumor …
Structures and Mechanisms in the cGAS-STING Innate Immunity …
Biochemical and structural studies have elucidated the mechanism of signal transduction in the cGAS pathway at the atomic resolution. This review focuses on the structural and mechanistic …
The neuroimmune nexus: unraveling the role of the mtDNA-cGAS …
2025年3月4日 · The relationship between Alzheimer's disease (AD) and neuroimmunity has gradually begun to be unveiled. Emerging evidence indicates that cyclic GMP-AMP synthase …
Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for …
2025年2月26日 · Cyclic GMP-AMP synthase (cGAS), a critical cytosolic DNA sensor initiating innate immune responses in the presence of cytosolic DNA, is increasingly recognized as a …
Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
2019年10月29日 · Sensing of cytoplasmic DNA by cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) results in production of the dinucleotide cGAMP …