Macrophages: shapes and functions - PMC - PubMed Central (PMC)
Classically activated, proinflammatory M1 macrophages depend to a large extent on glycolysis and produce lactate as the tricarboxylic acid cycle is blocked at two steps. Alternatively activated M2 macrophages prefer β-oxidation and oxidative phosphorylation to synthesize ATP (for an excellent review, see ). It is well established that ...
Modulation of macrophage phenotype by cell shape | PNAS
2013年10月7日 · We observed that macrophages exhibit different degrees of elongation when stimulated toward M1 or M2 phenotypes with cytokines in vitro. Using a micropatterning approach to control the shape of cells directly, we found that elongation of cells induced polarization toward an M2 phenotype.
PNAS丨M1-M2巨噬细胞形态学对比 - 知乎 - 知乎专栏
2023年9月11日 · Using a micropatterning approach to control macrophage cell shape directly, we demonstrate here that elongation itself, without exogenous cytokines, leads to the expression of M2 phenotype markers and reduces the secretion of inflammatory cytokines.
Modulation of macrophage phenotype by cell shape - PubMed
2013年10月22日 · Using a micropatterning approach to control macrophage cell shape directly, we demonstrate here that elongation itself, without exogenous cytokines, leads to the expression of M2 phenotype markers and reduces the secretion of inflammatory cytokines.
Macrophages: shapes and functions - PubMed
Here, their diverse functions in inflammation and tumor defense are described, and the mechanisms, tools, and activation pathways and states applied are presented. The main focus is on the role and origin of reactive oxygen species (ROS), the important signal pathways TLR/NF-κB, and the M1/ M2 polarization of macrophages.
Image based Machine Learning for identification of macrophage …
2017年6月14日 · We have confirmed the phenotypical difference between Naïve, M1 and M2 macrophages isolated from peripheral blood by classical techniques as found in the literature, namely qRT-PCR, cytokine...
Frontiers | From Monocytes to M1/M2 Macrophages: …
Macrophages are tissue sentinels that maintain tissue integrity by eliminating/repairing damaged cells and matrices. In this M2-like mode, they can also promote tumor growth. Conversely, M1-like macrophages are key effector cells for the elimination of …
New insights into M1/M2 macrophages: key modulators in …
M1 phenotype macrophages are tumor-resistant due to intrinsic phagocytosis and enhanced antitumor inflammatory reactions. Contrastingly, M2 are endowed with a repertoire of tumor-promoting capabilities involving immuno-suppression, angiogenesis and neovascularization, as well as stromal activation and remodeling.
Macrophages: shapes and functions | ChemTexts - Springer
2022年3月10日 · The main focus is on the role and origin of reactive oxygen species (ROS), the important signal pathways TLR/NF-κB, and the M1/ M2 polarization of macrophages. Macrophages are cells of the innate immune system and represent an important component of the first-line defense against pathogens and tumor cells.
New insights into M1/M2 macrophages: key modulators in …
2021年7月21日 · In this review, mechanisms underlying the distinct functional characterization of M1 and M2 macrophages are demonstrated to make sense of M1 and M2 as key regulators during cancer progression. Infiltration of macrophages in and around tumor nest represents one of the most crucial hallmarks during tumor progression.