头孢唑兰，本品是由日本武田公司最先研究开发的第四代头孢菌素。 1995年以Firstcin的商品名首次在日本上市，剂型为注射用粉针剂，规格为0.5g和1g。 我国尚未进口该品，亦未见国内厂家的相关研究报道。 按照《药品注册管理办法》，本品应属化药3（1）。 本品未在中国申请专利，也没有申请行政保护，因此不存在知识产权问题。 日本厚生省药检局批准的临床适用症为：败血症，外伤创口感染，以及由G+、G-和绿脓杆菌等引起的各种感染。 注射用粉针为0．5g和1g两种规 …

Cefozopran (INN) is a fourth-generation cephalosporin. [1] Most of the strains of Stenotrophomonas maltophilia have developed resistance toward cefozopran. [2] ^ Chang XM (December 1996). "Chapter 34: Market to Market". In Bristol JA (ed.). Annual Reports in Medicinal Chemistry. Vol. 31. San Diego, Calif.: Academic Press. p. 339.

2017年6月23日 · Cefozopran may decrease the excretion rate of Abacavir which could result in a higher serum level. The therapeutic efficacy of Abciximab can be decreased when used in combination with Cefozopran. The risk or severity of nephrotoxicity can be increased when Aceclofenac is combined with Cefozopran.

Cefozopran is a semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefozopran binds to and inactivates penicillin -binding proteins (PBPs) located on the inner membrane of the bacterial cell wall.

对健康受试者进行注射用盐酸头孢唑兰的药代动力学试验，测定头孢唑兰的经时血药浓度，计算头孢唑兰药代动力学参数，了解注射用盐酸头孢唑兰在人体吸收、分布、代谢、消除规律，为制定注射用盐酸头孢唑兰II期临床试验方案提供试验依据。 INTRODUCTION We investigated the drug resistance status of Pseudomonas aeruginosa (P. aeruginosa) focusing on its isolation sites and types of diseases.

Cefozopran is a commercial antibiotic that belongs to the class of 1,2,4-thiadiazole containing drugs, which have various biological activities. AI generated definition based on: Comprehensive Heterocyclic Chemistry IV, 2022

Cefozopran is a semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefozopran binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall.

2020年1月17日 · 用头孢他啶、头孢唑南 (cefuzonam)、氟氧头孢、头孢匹罗作对照，研究了本品对临床分离菌的抗菌活性，结果表明，本品对MSSA、链球菌属，除普通变形菌外的肠杆菌科的各种细菌、铜绿假单胞菌及流感嗜血菌等各种临床分离菌的MIC90在0.02～6.25 mL范围内。 其中，对MSSA和MSSE的MIC90分别为0，78和1.561xg/mL，其活性与头孢唑南、氟氧头孢、头孢匹罗相当，是头孢他啶的l6倍。 对MRSE，头孢他啶、氟氧头孢和头孢匹罗均不敏感 (其MIC90 …

头孢唑兰副作用;别名:头孢唑泮 Cefozopran、Firstcin、CZOP;头孢唑兰适应症:由本品敏感菌引起的败血症、外伤感染，呼吸系统、泌尿系统、腹腔、盆腔内化脓性炎症，眼科和耳鼻喉科炎症等。

Cefozopran is a semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefozopran binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the ...