Cefonicide (or cefonicid) is a cephalosporin antibiotic. [1] It has a density of 1.92g/cm 3. Injectable semi-synthetic cephalosporin antibiotic related to cefamandole, q.v. Cefonicid is synthesized conveniently by nucleophilic displacement of the 3-acetoxy moiety of 1 with the appropriately substituted tetrazole thiole 2.

2007年6月30日 · Cefonicid is a second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections. Cefonicid, like the penicillins, is a beta-lactam antibiotic.

第二代头孢菌素类抗菌素，对大多数革兰阳性球菌有抗菌作用，对革兰阴性杆菌的抗菌谱比第一代头孢菌素广，对大肠杆菌、肺炎杆菌、奇异变形杆菌等均有较强的抗菌作用。 用于敏感菌所致的尿路感染、皮肤及软组织感染、呼吸道感染、骨感染、淋病等。 [2] 头孢尼西钠为第二代广谱、长效的头孢类抗生素，通过抑制细菌细胞壁合成产生抗菌活性。 对革兰氏阳性和阴性菌以及一些厌氧菌均有抗菌作用。 对大多数β-内酰胺酶稳定。 革兰氏阴性需氧菌：卡他莫拉氏菌、催产克雷伯 …

Cefonicid is a second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.

Cefonicid is a 'second generation' cephalosporin administered intravenously or intramuscularly. It is similar to cefamandole in its superiority to first generation cephalosporins against several enterobacteriaceae as well as its activity against Haemophilus influenzae, including beta-lactamase-produ …

Cefonicid is a new second-generation cephalosporin with a broad antimicrobial spectrum of activity and a prolonged serum elimination half-life. It has good in vitro activity against methicillin-sensitive Staphylococcus aureus, nonenterococcal …

Cefonicid is a new second-generation cephalosporin with a broad antimicrobial spectrum of activity and a prolonged serum elimination half-life. It has good in vitro activity against methicillin-sensitive Staphylococcus aureus, nonenterococcal …

2012年11月3日 · Cefonicid has been used successfully in the treatment of patients with skin and soft tissue infections. 95 to 100% of treated patients have been cured, usually with a dose of 1g daily. In one comparative trial, cefonicid was as effective as cefazolin, the latter agent given in 3 divided daily doses.

2025年1月7日 · Cefonicid is a second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.

Cefonicid is usually well tolerated. In treating skin infections, cefonicid was usually less effective than cefazolin against Staphylococcus aureus. In genitourinary infections, cefonicid 1 g daily (as the sodium salt) in a single dose has shown comparable efficacy to cefamandole or amoxicillin given in multiple daily doses.