CDT1 (Chromatin licensing and DNA replication factor 1) is a protein that in humans is encoded by the CDT1 gene. [5] [6] [7] [8] It is a licensing factor that functions to limit DNA from replicating more than once per cell cycle.

2024年12月24日 · CDT1 (Chromatin Licensing And DNA Replication Factor 1) is a Protein Coding gene. Diseases associated with CDT1 include Meier-Gorlin Syndrome 4 and Meier-Gorlin Syndrome 1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Activation of the pre-replicative complex.

该基因编码的蛋白质参与了 DNA 复制所必需的复制前复合物的形成。 编码的蛋白质可以结合孪蛋白，从而防止复制，并可能起到防止这种蛋白质在不适当的起点开始复制的作用。 细胞周期蛋白 A 依赖性激酶对该蛋白质的磷酸化导致蛋白质降解。 [RefSeq 提供，2011 年 3 月] The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication.

2025年2月8日 · Cdt1 is phosphorylated and its degradation induced by Cdk2 and Cdk4; human CDT1 is essential for DNA replication and chromatin licensing; Cdt1 overexpression contributes to tumorigenecity by causing genomic instability in transgenic p53 knockout mice.

One of the mechanisms controlling the initiation of DNA replication is the dynamic interaction between Cdt1, which promotes assembly of the pre-replication license complex, and Geminin, which inhibits it. Specifically, Cdt1 cooperates with the …

2016年12月22日 · The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is also required during mitosis. Tight cell cycle controls over Cdt1 abundance and activity are critical to normal development and genome stability.

2023年1月5日 · Cells must avoid licensing of neosynthesized DNA to prevent rereplication. In this issue of Molecular Cell, Ratnayeke et al. (2022) 1 reveal how the licensing factor CDT1, prior to its degradation, inhibits DNA elongation by suppressing CMG …

2007年1月1日 · Cdt1 is regulated over the course of the cell cycle mainly by the controlled expression of an inhibitor protein, geminin, and the level of Cdt1 periodically fluctuates due to ubiquitination and proteolysis.

2012年5月13日 · Cdt1, a protein critical for replication origin licensing in G1 phase, is degraded during S phase but re-accumulates in G2 phase. We now demonstrate that human Cdt1 has a separable essential...

The CDT1 gene provides instructions for making a protein that is important in the copying of a cell's DNA before the cell divides (a process known as DNA replication). Learn about this gene and related health conditions.