Cadherin-17 is a protein that in humans is encoded by the CDH17 gene. [5][6][7] This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane …

Jul 19, 2022 · CDH17 is a Ca2+-dependent cell adhesion molecule that can activate cell adhesion signals after binding to integrin molecules such as integrin α2β1 (Figure 2).

Apr 1, 2024 · Cadherin-17 (CDH17) is a membranous cell adhesion protein predominantly expressed in intestinal epithelial cells. CDH17 is therefore considered a possible diagnostic …

Jan 24, 2024 · Cadherin-17 (CDH17), a marker of differentiation in intestinal cells, binds and activates α2β1 integrin to promote cell adhesion and proliferation in colorectal cancer (CRC) …

Mar 22, 2024 · Our new CDH17/PD-1 bispecific antibody would reactivate anti-tumor immunity with reduced risk of on-target off-tumor toxicity. Different bispecific antibody formats were …

Oct 20, 2016 · CDH17 is a specific and more sensitive marker in the gastrointestinal tract than CK20 and CDX2. CDH17 may be especially valuable when gastrointestinal tumors are …

Cadherin-17 (CDH17) is an oncofetal molecule associated with poor prognostic outcomes of hepatocellular carcinoma (HCC), for which the treatment options are very limited. The present …

Mar 22, 2024 · Our ADC is designed to deliver MMAE specifically to CDH17-expressing tumors to exert the cytotoxic effect of MMAE on cancer cell, mitigating the undesired off-target …

Apr 22, 2013 · Cadherin-17 (CDH17) is a non-classical, seven domain, cadherin lacking the conserved cytoplasmic domain of classical cadherins. CDH17 was overexpressed in highly …

Cadherin‐17 (CDH17), a marker of diferentiation in intestinal cells, binds and activates α2β1 integrin to promote cell adhesion and proliferation in colorectal cancer (CRC) metastasis. …