Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene. [5] [6] The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication.

细胞分裂周期蛋白6（CDC6）在DNA复制过程中发挥重要作用。作为前复制复合物（pre-RC）中的核心成员，如果CDC6发生突变或缺失，pre-RC将无法组装，DNA复制也会受到抑制。由于CDC6在细胞周期进程中扮演着关键角色，…

2024年12月24日 · CDC6 (Cell Division Cycle 6) is a Protein Coding gene. Diseases associated with CDC6 include Meier-Gorlin Syndrome 5 and Meier-Gorlin Syndrome 1. Among its related pathways are Activation of the pre-replicative complex and CDK-mediated phosphorylation and removal of Cdc6.

2007年11月28日 · Cell division cycle 6 (CDC6) is an essential regulator of DNA replication in eukaryotic cells. Its best-characterized function is the assembly of prereplicative complexes at origins of replication during the G 1 phase of the cell division cycle.

MCM、Cdc6、Cdt1、ORC等形成复制前复合物（pre-replication complex），又称为复制准许因子（replication license factor，RLF），激活后启动DNA复制。

2021年6月23日 · The structure reveals that Cdc6 contributes to origin DNA recognition via its winged helix domain (WHD) and its initiator-specific motif.

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase.

周期蛋白6(cdc6)是组成前复制复合物(pre-rc)的主要蛋白之一,控制细胞从g1期进入s期,同时也参与激活和维持有丝分裂s-m期检测点机制.最近的研究发现其也具有原癌基因的特性,并在人多种肿瘤细胞中存在高表达,对肿瘤发生发展起重要作用.cdc6致癌机制可能与ink4/arf ...

Cell division cycle protein, CDC6, is essential for the initiation of DNA replication. CDC6 was recently shown to inhibit the microtubule-organizing activity of the centrosome. Here, we show that CDC6 is localized to the spindle from pro-metaphase I …

2024年6月5日 · 细胞分裂周期蛋白6（Cell division cycle 6，CDC6）属于AAA+ATP酶家族成员，是DNA复制起始阶段的主要调控因子之一。CDC6不仅在DNA复制起始阶段发挥功能，而且在G1期以外也发挥着重要功能。鉴于CDC6在细胞周期进展中发挥重要作用，其表达异常会导致多种 …