M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.

CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically …

在G2期和有丝分裂早期，CDC25A/B/C介导的去磷酸化激活CyclinA/B-CDK1复合物。该复合物磷酸化几种底物，这些底物至少触发中心体分离、高尔基动力学、核膜破裂和染色体浓缩。

2025年3月28日 · CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is …

Cell division cycle 25 A (Cdc25A), a dual-specificity protein phosphatase, is one of the most crucial cell cycle regulators, which removes the inhibitory phosphorylation in cyclin-dependent …

2021年8月6日 · Here we describe a novel ubiquitin/proteasome-mediated pathway negatively regulating CDC25A stability, dependent on its phosphorylation by the serine/threonine kinase …

2020年12月1日 · 哺乳动物至少有3种cdc25磷酸酶亚型，分别为cdc25a、cdc25b和cdc25c。近年来的研究显示，cdc25a主要在细胞的g1/s期转变中发挥作用，cdc25b在s期被激活，继而在细 …

2016年4月21日 · We report here on a genome-wide CRISPR-Cas9 screen that identified CDC25A as a major determinant of sensitivity to ATR inhibition. CDC25A-deficient cells resist high …

2025年2月8日 · CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is …

2025年1月4日 · CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is …