Cdc25 activates cyclin dependent kinases by removing phosphate from residues in the Cdk active site. In turn, the phosphorylation by M-Cdk (a complex of Cdk1 and cyclin B) activates Cdc25. Together with Wee1, M-Cdk activation is switch-like. The switch-like behavior forces entry into mitosis to be quick and irreversible.

2020年12月1日 · 艾美捷科技作为专业的生命科学领域解决方案供应商，为您推荐的细胞分裂周期因子25 (Cdc25)检测试剂盒，可用于高通量蛋白磷酸酶Cdc25A、Cdc25B和Cdc25C的抑制剂和调节剂的筛选：

Cell division cycle 25 (CDC25) phosphatases are key regulators of the eukaryotic cell cycle. They are required to control cyclin-dependent kinase (CDK) dephosphorylation and activation in a...

The Cdc25 phosphatases are cell cycle control proteins whose overexpression is frequently associated with a wide variety of cancers. In this review of the Cdc25 phosphatases, we first consider the role of Cdc25 in cell cycle control and oncogenic transformation, and then discuss 20 different reports of Cdc25 overexpression in human cancers.

2020年6月3日 · CDC25C is a cyclin of the specific phosphatase family that activates the cyclin B1/CDK1 complex in cells for entering mitosis and regulates G2/M progression and plays an important role in checkpoint protein regulation in case of DNA damage, which can ensure accurate DNA information transmission to the daughter cells.

CCDC25存在于癌细胞的表面，可以高特异性和亲和性与NET DNA结合，使癌细胞能够感知NET。 令人印象深刻的是，研究者们还鉴定出了CCDC25与NET DNA结合的特定细胞外部分。 研究证实，NET介导的癌细胞迁移刺激是由CCDC25驱动的。 因为，当从体外培养的人类乳腺癌细胞或患者的原代乳腺癌细胞样本中去除CCDC25，在体外测试中，癌细胞的迁移大大下降。 与CCDC25仍然存在的小鼠相比，将CCDC25从小鼠癌细胞表面去除，显著减少了肝脏转移的形成，同时还减 …

Members of the eukaryotic Cdc25 phosphatase family are key targets of the Chk1 and Chk2 checkpoint kinases, which inactivate Cdc25 to halt cell cycle progression when DNA is damaged or incompletely replicated. Now, new kinases that phosphorylate and inactivate Cdc25 are being discovered, including M …

2015年1月30日 · Cdc25C (cell division cycle 25C) phosphatase triggers entry into mitosis in the cell cycle by dephosphorylating cyclin B-Cdk1. Cdc25C exhibits basal phosphatase activity during interphase and then...

Cell division cycle 25 A (Cdc25A), a dual-specificity protein phosphatase, is one of the most crucial cell cycle regulators, which removes the inhibitory phosphorylation in cyclin-dependent kinases (CDKs), such as CDK2, CDK4, and CDK6, and positively regulates the activities of CDKs that lead to cell cycle progression.

Cell Division Cycle-25 (CDC25) plays an important role in transitions between cell-cycle phases by dephosphorylating and activating CDKs. CDC25B and CDC25C play a major role in G2/M progression, whereas CDC25A assists in G1/S transition. Different isomers of CDC25 expressions are upregulated in various clinicopathological situations.