2020年4月28日 · CD9, a 24 kDa tetraspanin membrane protein, is known to regulate cell adhesion and migration, cancer progression and metastasis, immune and allergic responses, and viral infection. CD9 is...

cd9是一个多次跨膜蛋白，强烈建议提取蛋白时不煮样，防止蛋白聚集；表达量较低的细胞可通过提取膜蛋白富集靶标蛋白。 在对外泌体进行cd9检测时，cd9的蛋白丰度十分重要，若提取的外泌体中cd9含量较低，易出现无信号现象。

2019年4月13日 · Silencing tetraspanin CD 9 both in EV s and recipient cells strongly decreased the endocytosis of EV s and abolished the nuclear transfer of their cargos. Here, we investigated whether monovalent Fab fragments derived from 5H9 anti‐ CD 9 monoclonal antibody (referred hereafter as CD 9 Fab) interfered with these cellular processes.

2023年9月19日 · 一方面，cd9作为肿瘤抑制因子或肿瘤促进剂的影响肿瘤发生或转移；另一方面，cd9 的影响肿瘤转移级联，如原发性肿瘤逃逸、内渗、外渗、定植和继发性肿瘤的生长；最后，cd9 也可能促进肿瘤血管和淋巴管生成，从而影响肿瘤的复发、进展和定植。

CD9, which belongs to the tetraspanin membrane proteins, is implicated in several pathological processes, including tumor progression. However, the role of CD9 in the pathogenesis of Ph+ ALL and the potential benefit of applying CD9‑targeted RNA interference strategies for treatment of Ph+ ALL require further investigation.

2020年3月30日 · Here we report the crystal structure of CD9 and the cryo-electron microscopic structure of CD9 in complex with its single membrane-spanning partner protein, EWI-2.

Fusobacterium-associated defensin inducer (FAD-I) is the principal F. nucleatum agent for hBD2 induction in human oral epithelial cells via TLR-1/2 and TLR-2/6 . NOD-like receptors are normally composed of a central conserved NOD domain, a C-terminal LRR, and an N-terminal effector domain [ 62 , 63 ].

At the IS, CD9 on the T cell side regulates the clustering and adhesive activity of integrins LFA-1 (αLβ1) and VLA-4 (α4β1), whereas on the APC side, CD9 regulates the expression of ALCAM/CD166 and the avidity of its interaction with CD6.

2024年5月1日 · CD9 overexpression has been found to promote cell proliferation, migration, and invasion, as well as resistance to apoptosis. 1, 4 The effects of CD9 overexpression can vary depending on the specific cell type, the level and duration of overexpression, and other factors. 2, 5 Further research is needed to fully understand the mechanisms ...

2000年2月1日 · We tested the effects of an anti-CD9 monoclonal antibody (ALMA.1) on the migration and proliferation of human vascular endothelial cells (ECs) during repair of an in vitro mechanical wound mimicking angiogenic processes. ALMA.1 induced dose-dependent inhibition of wound repair with a 35±1.5% decrease at 20 μg/mL.