Wildtype C57BL/6 inbred mice express the Ptprc b (CD45.2 or Ly5.2) allele. A CRISPR-generated coisogenic C57BL/6J strain expressing CD45.1 is now available as Stock No. 033076 .

Detailed analysis of CD45.1 and CD45.2 strains, enabled researchers to identify a key difference in expression of natural cytotoxicity receptor 1 (NCR1) on NK cells between the two strains, …

2023年11月8日 · CD45.1/CD45.2 congenic markers have been used to track hematopoietic lineage differentiation following hematopoietic stem and progenitor cell (HSPC) …

CD45 is an essential protein on the surface of cells of the haematological and immunological systems. It has been used as a diagnostic tool to identify cells of haematological origin, but its …

2023年11月28日 · The B6 (C57BL/6J) strain, which expresses the CD45.2 isoform, was crossed with the SJL mouse expressing the CD45.1 isoform to introduce the CD45.1 gene on a B6 …

This review aims to summarize recent findings on the role of CD45 and CD45-associated molecules in T cell activation, and to highlight issues that seem relevant to ongoing research in …

2025年3月30日 · PTPRC (Protein Tyrosine Phosphatase Receptor Type C) is a Protein Coding gene. Diseases associated with PTPRC include Immunodeficiency 105, Severe Combined …

2025年2月7日 · Taconic Biosciences offers a B6.SJL mouse model that, by current nomenclature, carries the Ptprca allele from SJL, giving it Ly5.1 (Cd45.1) antigen specificity.

2017年6月14日 · We performed bone marrow transplants with wild-type CD45.1 and CD45.2 donor cells, and characterised haematopoietic cell reconstitution in dual-expressing CD45.1/2 …

2024年12月17日 · Mutation details: Ptprc a is found in strains SJL/J, STS/A, and DA. Ptprc b is found in strains C57BL/6, C3H/An, DBA/2, AKR, and many others (J:13367, J:12054, J:12077, …