急性白血病的“照妖镜”？流式细胞术来帮你 - 澎湃新闻
2020年9月4日 · aml-m6是红系发生恶性增殖，表现为病态红系增生，原始细胞表达红系特异性标志cd235a。 aml-m7比较少见，主要是巨核细胞发生恶性增殖，原始细胞表达巨核特异性标 …
Potent and Effective Targeting of AML with ‘Off-the-Shelf’ …
2024年11月5日 · DKO CD45CAR T-cells expressing a YTH24.5-CD28zeta CAR showed optimal function, efficiently killed CD45 + AML cell lines in vitro and demonstrated antigen-specific …
Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia
A flow cytometry method has been introduced into the routine investigation of whole bone marrow samples following red blood cell lysis on the basis of a primary CD45/side scatter (SSC) gating …
Simultaneously targeting CD45 significantly increases cytotoxicity …
2008年5月1日 · We herein tested whether simultaneous targeting of CD45 could improve GO cytotoxicity against AML cell lines and primary AML cells. We found that the anti-CD45 …
CD45 correlates with adverse risk stratification, decreased
Results: CD45 high expression (CD45high) was associated with higher risk stratification in elderly AML patients (P= 0.021). The percentage of CD45high cases in CR patients was 16.4%, …
CD45
2020年4月6日 · Leukemia stem cells (LSCs) in play an important role in the initiation, relapse, and progression of acute myeloid leukemia (AML), and in the development of chemotherapeutic …
We show that the CD45/SSC gating pro-cedure improved phenotypic determination of the blast cells in three ways: (1) by discriminating between leukemic blast cells and residual normal …
CD45 phosphatase is crucial for human and murine acute myeloid leukemia ...
CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. Exploiting CD45 KO mice and lentiviral shRNA, we …
Potent and Effective Targeting of AML with ‘Off-the-Shelf’ …
2024年11月5日 · Our data confirm that CD45 is an excellent candidate for CAR T-cell therapy in AML. We have demonstrated that DKO CD45CAR T-cells show potent anti-leukemic activity …
CD45-Directed CAR-T Cells with CD45 Knockout Efficiently Kill …
2024年1月12日 · CD45 is expressed on almost all types of blood cells including myeloid leukemia cells, but not on non-hematopoietic tissue, making it a potential target for CAR-directed …