双热点重磅综述丨少有人知的细胞外基质（ECM）和免疫系统对话
一方面，HA可通过CD44（大多数白细胞中的HA受体）与细胞表面结合，在缺乏其他粘附分子的情况下使中性粒细胞粘附，HA-CD44的相互作用对白细胞迁移和定位至关重要。
The role of CD44 in epithelial–mesenchymal transition and cancer ...
CD44 plays pivotal roles in promoting tumor invasion and metastasis by contributing to adhesion of tumors cells to endothelium and fibronectin-enriched matrices. 68 CD44v possesses E …
CD44: structure, function, and association with the malignant
CD44 is a multifunctional receptor involved in cell-cell and cell-ECM interactions, cell traffic, lymph node homing, presentation of chemokines and growth factors to traveling cells, and …
CD44: A Multifunctional Mediator of Cancer Progression - PMC
CD44 interacts with various ECM components, proteins and cytokines present in the tumour microenvironment. Interaction between ligands such as hyaluronan (HA), osteopontin (OPN) …
CD44: From adhesion molecules to signalling regulators - Nature
2003年1月1日 · First, CD44 can act as a ligand-binding receptor by interacting with the ECM and other extracellular components, or can function as a specialized 'platform' for growth factors …
CD44 Is Associated with Poor Prognosis of ccRCC and ... - PubMed
2023年7月24日 · Results: CD44 was significantly upregulated in ccRCC and associated with poor overall survival (OS). Based on the functional enrichment analysis and PPI network, we found …
Regulation of antigen-experienced T cells: lessons from the ...
2012年2月26日 · The best-established function of CD44 is the regulation of cell adhesion and migration. As such, the interactions of CD44, primarily with its major ligand, the extracellular …
靶向肿瘤干细胞的药物开发靶点：CD44 - 知乎
CD44以HA依赖性或HA非依赖性参与调节 MMPs 表达，特别是MMP2和MMP9，降解细胞外基质（ECM），促进肿瘤的侵袭和转移。 CD44调节细胞周期相关蛋白的水平，包括细胞周期蛋 …
ITGB1/FERMT1 mechanoactivation enhances CD44 characteristic
2025年3月5日 · Here, our findings link ECM mechanical stimuli to CSCs phenotype transition, and propose that ECM stiffening mechanoactivates tumor cells to dedifferentiate and acquire CD44 …
吞噬细胞糖蛋白1 (CD44)-丁香实验
2010年12月2日 · CD44分子胞膜外区远膜区的连接组件可结合ECM中的透明质酸 (HA)及多种ECM，如胶原 (CO)、纤连蛋白 (FN)和层黏连蛋白 (1N)，以分子上的硫酸软骨素 (CS)发挥黏 …