2025年3月28日 · CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex) is a Protein Coding gene. Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are Immune response NFAT in immune response and TCR Signaling (Qiagen).

CD3抗原是T细胞表面的重要标志，与 TCR 以非共价键结合形成TCR/CD3受体复合物。CD3包括四条蛋白链，分别为CD3δ, CD3ε, CD3γ 和 CD3ζ，其中CD3δ/CD3ε, CD3γ/CD3ε以异源二聚体形式和TCR的α/β链形成TCR-CD3复合物。 在抗原刺激后，CD3胞质区尾部的结构发生构象变化，如 LCK (淋巴细胞特异性蛋白酪氨酸激酶)和 Src家族蛋白酪氨酸激酶 等，将CD3复合物的ITAM (免疫受体酪氨酸激活基序)中的酪氨酸残基磷酸化，得到SH2结构域的蛋白结合位点，另 ZAP70， …

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3- gamma, - delta and - zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor - CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1] . It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.

CD3蛋白是免疫系统中关键的分子之一，参与激活细胞毒性T细胞 (CD8+初始T细胞)和T辅助细胞 (CD4+初始T细胞)，负责监测和抵御体内的感染和异常细胞。 CD3的定义和结构：CD3由四条不同的链组成：包括CD3δ、CD3ε、CD3…

2025年3月8日 · The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

2020年8月20日 · Collectively, CD3ε is a built-in multifunctional signal tuner, and increasing CD3 diversity represents a strategy to design next-generation CAR. Keywords: CAR-T therapy; Csk; ITAM; T cell receptor; TCR; cancer; cell persistence; cytokine release; p85; phosphorylation pattern; quantitative mass spectrometry. Copyright © 2020 Elsevier Inc.

您可点击此处下载T-cell surface glycoprotein CD3 epsilon chain（CD3E）靶点介绍及实验小贴士pdf文件。 图一：人T cell receptor-CD3复合体蛋白结构。 图片来源：SWISS-MODEL。 IHC实验贴士. CD3是T细胞标记物。 TCR:CD3复合体是是一种多亚基蛋白复合物，它由与抗原结合的TCR（T细胞受体）αβ异源二聚体，和CD3的4个肽链（包括ε、γ、δ和ζ）形成的εγ、εδ和ζζ 3个二聚体组成。 所有CD3肽链的胞质结构域都含有基于免疫受体酪氨酸的激活基序 (ITAMs)。 …

cd3e是t细胞受体（tcr）信号传导复合物的一部分，与tcrαβ或tcrγδ亚单位非共价结合。其作用机制是在t细胞受体识别并结合到主要组织相容性复合物（mhc）呈递的抗原肽时，cd3e与其他cd3分子协同，传递激活信号，导致t细胞的激活。

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.