Mar 30, 2025 · CD27 (CD27 Molecule) is a Protein Coding gene. Diseases associated with CD27 include Lymphoproliferative Syndrome 2 and Combined T Cell And B Cell Immunodeficiency. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.

CD27 is a costimulatory molecule associated with CD27 Deficiency, a condition characterized by immunodeficiency, EBV lymphoproliferative disease, reduced T cell proliferation, and progressive hypogammaglobulinemia.

The Traf-linked tumor necrosis factor receptor family member CD27 is known as a T cell costimulatory molecule.

Feb 28, 2023 · CD27 is a marker for IgG class switched memory (CD27+ IgD- IgM-) versus naïve B cells (CD27- IgD+ IgM+) (J Exp Med 1998;188:1679) Triggering of CD27 by CD70 leads to shedding of soluble CD27 from cells by a protease ( J Immunol 1991;147:29 )

Feb 13, 2024 · CD27-costimulated chimeric antigen receptor (CAR)-engineered T cells exhibited improved tumor control compared with CD28-costimulated CAR-T cells. Thus, CD27 signaling during Tn cell activation promotes memory properties with relevance to T cell immunotherapy.

The CD27 agonistic antibody varlilumab showed promising efficacy in haematological as well as solid cancers. Current studies investigate the combination of the CD27 agonistic antibody varlilumab in combination with the PD1 axis targeting immune checkpoint inhibitors like nivolumab or atezolizumab.

May 1, 2000 · Memory B cells generate immunoglobulins rapidly and vigorously in the secondary immune response. Here, Kazunaga Agematsu and colleagues highlight studies confirming that CD27 is a memory B-cell marker.

Mar 8, 2009 · Here we show that most γδ T lymphocytes expressed the tumor necrosis factor receptor family member CD27 and secreted interferon-γ, whereas interleukin 17 production was restricted to CD27− ...

Jun 23, 2017 · Since CD27 mRNA was highly expressed in BCR-ABL1 and CRLF2-rearranged/high BCP-ALL that are associated with poor prognosis, we asked whether CD27 has prognostic value.

CD27 is a member of the tumor necrosis factor (TNF) receptor superfamily and is expressed on T, B, and NK cells. The signal via CD27 plays pivotal roles in T-T and T-B cell interactions. Here we demonstrate that overexpression of CD27 activates NF-κB and stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK).