bcma（cd269；tnfrsf17）也是肿瘤坏死因子受体超家族的一员，于20世纪90年代初首次被发现。这种184个氨基酸的糖蛋白在b细胞成熟和分化为浆细胞中起主要作用。

B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene. TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). [5][6][7]

2020年2月13日 · B-cell maturation antigen, also referred to as TNFRSF17 or CD269, is a member of the tumor necrosis factor receptor (TNFR) superfamily [6, 7]. Ligands for BCMA include B-cell...

CD269, also known as B cell maturation antigen (BCMA), is a 27 kD, single pass transmembrane protein with one TNFR-Cys repeat on its extracellular domain. CD269 is a B cell maturation factor, essential for the long-term survival of plasma cells.

2024年8月20日 · bcma是肿瘤坏死因子受体超家族成员17（tnfrsf17），也称为b细胞成熟抗原（cd269），促进b细胞存活并在调节体液免疫中发挥作用。 BCMA在多发性骨髓瘤（MM）中高表达，BCMA是MM诊断的生物标志物。

TNFRSF17是TNF-receptor家族的一员，被称为肿瘤坏死因子受体超家族成员17，又名B细胞成熟抗原(BCMA或BCM)或CD269，它是由TNFRSF17基因编码的蛋白质。 该受体表达于B淋巴细胞及浆细胞表面，是一种B淋巴细胞成熟的标…

CD269 (BCMA) functions as a B cell maturation factor that is essential for the survival of long-lived bone marrow plasma cells. A soluble form of CD269 (BCMA) is generated by γ-secretase that can regulate plasma cell survival and differentiation.

作为一种更具选择性的治疗候选抗原，b 细胞成熟抗原 (bcma/tnfrsf17/cd269) 受到了重点关注。 BCMA 是一种属于 TNFR 超家族的跨膜蛋白，并且几乎只在成浆细胞和分化的浆细胞表面表达。

CD269 promotes B cell survival and plays a role in the regulation of humoral immunity. Binding of CD269 to CD257 blocks the binding of CD257 to its receptor on the plasma membrane and inhibits CD257-triggered B lymphocyte costimulation. Overexpression of CD269 activates NF-κB and JNK, and this activation is potentiated by CD257.

bcma（cd269；tnfrsf17）也是肿瘤坏死因子受体超家族的一员，于20世纪90年代初首次被发现。这种184个氨基酸的糖蛋白在b细胞成熟和分化为浆细胞中起主要作用。