Dipeptidyl peptidase-4 (DPP4 or DPPIV), also known as adenosine deaminase complexing protein 2 or CD26 (cluster of differentiation 26) is a protein that, in humans, is encoded by the DPP4 gene. [5] DPP4 is related to FAP, DPP8, and DPP9.

CD26 is a widely distributed 110 kD cell-surface glycoprotein with known dipeptidyl-peptidase IV (DPP-IV) activity in its extracellular domain. This ecto-enzyme is capable of cleaving amino terminal dipeptides from polypeptides with either L-proline or L-alanine in the penultimate position.

2018年4月5日 · In the present study by Zhao, Fan and colleagues, authors investigate the role of CD26 as a costimulatory molecule for T-cell activation after skin allotransplantation. 10 In a diverse and well...

CD26, being an adenosine deaminase binding protein (ADAbp), functions as a receptor for ADA on lymphocytes. The focus of this review is the structure and function of CD26 and the influence of its ligand binding activity on T-cell proliferation and the T cell costimulatory activity of CD26.

cd26是一种多功能分子，除参与营养物质的转运与再循环并作为一种粘附分子结合胶原蛋白和纤维连接蛋白外，最近的进展表明cd26对免疫系统具有重要作用，特别是在t细胞活化、scid、hiv感染及自身免疫病等方面有重要的意义。

2008年8月25日 · CD26 is another surface antigen with demonstrated utility in the diagnosis of T-cell neoplasms in the peripheral blood. This antigen is broadly expressed, and has multiple biological functions (reviewed in Ref. 1), including enzymatic activity as a dipeptidyl-peptidase (DPP IV). CD26 is upregulated in vitro by T cell activation.

二肽基肽酶-4（ dipeptidyl peptidase-4 ，DPP-4）又称T细胞表面抗原CD26，是一种跨膜丝氨酸多肽酶，分布广泛，作用多向 [1] 。 可作为 二肽酶 水解多肽，从而调节肽类激素、神经肽、细胞因子和生长因子的活性，另可作为表面抗原与其他分子或蛋白共同合作，介导 ...

Immune system CD4 T-cells with high cell-surface CD26 expression show anti-tumoral properties. When engineered with a chimeric antigen receptor (CAR), they incite strong responses against solid cancers. This subset was originally associated to human ...

1999年8月1日 · Here, we summarize recent findings on molecular and functional characteristics of CD26. We argue that a multidisciplinary approach might reveal the molecular events underlying the role of CD26 in HIV infection and immune, inflammatory and endocrine responses.

2008年6月1日 · CD26 expression is elevated after activation of resting T cells. Human CD26 high T cells respond maximally to recall antigens such as tetanus toxoid, leading to T cell proliferation. Crosslinking of CD26 and CD3 on T cells with plate-bound monoclonal antibodies (mAbs) induces their proliferation and IL-2 production.