2019年4月11日 · CD22 popped up in screening for suppressors of microglial phagocytosis. The receptor is upregulated in aging mice and in Alzheimer’s. Blocking CD22 improves phagocytosis and memory in old mice.

2021年12月8日 · In human brain, CD22 is expressed in oligodendrocytes, its receptor on microglia. Binding of sCD22 to IGFR2 scrambles lysosomal trafficking, and lipids build up. Blocking this binding restored lysosomal function.

2022年4月26日 · Wyss-Coray and colleagues previously reported that microglia in aged mice express CD22, which functions as an inhibitory receptor of phagocytosis ( Pluvinage et al., 2019 ). Although their follow-up study ( Pluvinage et al., 2021) did not find expression of CD22 in human microglia, they found that human oligodendrocytes release soluble CD22 (sCD22) which binds …

2019年4月11日 · Pluvinage JV, Haney MS, Smith BA, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T . CD22 blockade restores homeostatic microglial phagocytosis in ageing brains . Nature. 2019 Apr;568 (7751):187-192. Epub 2019 Apr 3 PubMed .

2021年12月8日 · The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Sci Transl Med. 2021 Dec;13 (622):eabg2919. PubMed.

23 Apr 2019 Much of the research on microglia in Alzheimer’s disease has focused on the TREM2 receptor (see Part 4 of this series). But other microglial receptors play a hand in age- and injury-related activation as well (e.g., Apr 2019 news on CD22). One is CD33, a known AD gene that encodes another transmembrane receptor on these cells. There is a protective CD33 variant, …

2023年4月18日 · Microglia Need Scara1 Receptor to Clear Soluble Amyloid 28 Jun 2013 Protective Microglial Gene Variant Promotes Phagocytosis 22 Aug 2013 Scientists Seek, Find, and Exploit AD Risk Genes 17 Dec 2014 Antibodies Boost Microglial Appetite for Tau 11 Jun 2015 CD22 Suppresses Microglial Phagocytosis—A New Therapeutic Target? 5 Apr 2019

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2004年6月23日 · Clonality: monoclonal Host: Mouse Isotype: IgG 1 κ Source: DAKO Cat# TC668 Formulation: FITC, RPE and APC. Purified Reactivity: Reacts in: Human Specificity Triple-Colour Reagent, Anti-Human TdT/FITC Anti-Human CD22/RPE Anti-Human CD3/APC; simultaneous detection and enumeration of T and B-lymphocyte precursor cells, B cells and T cells …

2025年1月8日 · Mutations in NPC1 cause Niemann-Pick Type C. Mice lacking NPC1 only in microglia have rampant neuroinflammation and impaired neuronal metabolism. In children with NPC, the microglial marker TSPO tracks with neurodegeneration. Siblings with the same mutation can have different symptoms and ages of onset.