2023年12月26日 · m2巨噬细胞的主要标记是 cd163 和cd206。此外，精氨酸酶1（arg1）和dectin-1也是用于鉴定m2巨噬细胞的理想表型指标。 研究还显示，fizz1、ym1和ly6c 也可以用作与m1或m2巨噬细胞亚群相关的表面标记。

CD206, also known as mannose receptor C type 1 (MRC1), is a cell-surface protein abundantly presents on selected populations of macrophages and dendritic cells. 16 As for macrophages, CD206 is normally expressed on the M2 but not M1 subtype and therefore serves as a useful marker to identify the M2 phenotype.

2022年11月21日 · We show that depletion of CD206 + M2-like macrophages activates FAPs and activated FAPs secrete follistatin, a promyogenic factor, thereby boosting the recovery process. Conversely, deletion of...

2017年8月18日 · We show that adipose tissue CD206 + cells are primarily M2-like macrophages, and ablation of CD206 + M2-like macrophages improves systemic insulin sensitivity, which was associated with an...

2019年11月3日 · Further analysis revealed that CD206, a M2 marker gene, could faithfully reflect variation in M2 fractions and was more highly expressed in AML than normal controls. High CD206 expression predicted inferior overall survival (OS) and event-free survival (EFS) in two independent AML cohorts.

CD206 是M2型巨噬细胞特异性的检测靶点, Teesalu 等通过噬菌体展示技术筛选了靶向CD206的多肽CSPGAKVRC (UNO). FAM修饰的UNO与CD206抗体共定位成像小鼠乳腺癌组织, 并用于胶质母细胞瘤、胃癌和黑色素肿瘤的组织成像。 Scodeller 等人在携带 4T1 转移性乳腺肿瘤 的小鼠体内进行了体内肽噬菌体展示筛选，以识别靶向腹膜巨噬细胞的肽。 他们发现了一种肽UNO，其通过CD206曼糖受体选择性识别表达MRC1的TAMs。 单字母 H2N-CSPGAKVRC-OH. 多字母 …

2020年10月23日 · In this study, we investigated the role of M2 MΦ in implantation using CD206-DTR mice. To deplete M2-MΦ, female CD206-DTR C57/BL6 mice were injected with DT before implantation. These M2-MΦ depleted mice (M2 (-)) were naturally mated with Balb/C mice.

cd206是m2型巨噬细胞标志物，具有高度特异性，与肿瘤细胞的增殖和转移密不可分。 已有研究表明CD206与乳腺癌、卵巢癌、胰腺癌、前列腺癌等恶性肿瘤密切相关，深化对CD206的研究对阐述肿瘤免疫微环境的形成机制、寻找更具针对性的靶向药物有一定的临床指导 ...

2019年12月10日 · CD206 is a mannose receptor expressed on alternatively activated macrophages, termed M2 macrophages. M2 macrophages have an anti-inflammatory phenotype to resolve excess inflammation,...

CD206 is a highly specific marker for M2 macrophages 8 that lacks intracellular signaling motifs, thus is generally considered to function as an endocytic receptor for the internalization of extracellular substances for clearance or antigen presentation 9.