006785 B6.129P2(C)- Cd19 tm1(cre)Cgn /J The CD19-Cre knock-in/knock-out allele has a Cre recombinase gene inserted into the first coding exon of the CD19 antigen gene; both abolishing endogenous Cd19 gene function and placing cre expression under the control of the endogenous Cd19 promoter/enhancer elements.

CD19-Cre mice were constructed by inserting a Cre recombinase gene expression element into the endogenous Cd19 gene of mice to drive its specific expression. A "Rabbit β-globin intron" is attached downstream of the Cre recombinase gene expression element, which can greatly increase the expression level of Cre recombinase.

Cd19-Cre小鼠是通过将Cre重组酶基因表达元件插入到小鼠内源性Cd19基因中，驱动其特异性表达而构建的。 该Cre重组酶基因表达元件的下游连接了一个“Rabbit β-globin intron”基因表达元件，可以极大地增强上游Cre重组酶基因的表达。

2021年3月9日 · CD19-Cre and Mb1-iCre transgenic mice are commonly used for generating B cell-specific KO mice and investigate the development, as well as the physiological and pathophysiological roles of B...

鉴于 B 淋巴细胞在炎症和病原体免疫防御中的重要性，Cd19 启动子控制下的 Cre 转基因小鼠（Cd19Cre/+ 小鼠）已被广泛用于专门研究 loxP 侧翼基因在 B 细胞发育/功能中的作用.

很多Cre，比如Cd19-Cre, 是替代了基因组中原有基因的位置；还有一些Cre，比如Foxp3-Cre, 是插入了内源基因的3’UTR 的位置。 这两点有可能造成Cre插入事件对于内源基因表达造成显著影响，例如有些基因的杂合子和纯合子表达基因量不同导致下游信号强度差异，或者 ...

Tamoxifen诱导Cre-ERT2小鼠 使用指南. Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。 查看

2025年1月8日 · CD19-Cre is an important and widely used Cre-lox model for B cell-specific genetic manipulation in murine systems. Mice carrying one allele of CD19-Cre are, at the same time, rendered...

CD19-cre小鼠是什么？ CD19-creBiblioteka Baidu鼠介绍 B细胞特异表达cre，与带有两个FloxP位点的FloxP小鼠交配后，在Cre特异表达的组织或者器官或细胞中，目标基因中两个FloxP位点间的外显子或元件将被删除，达到条件性敲除或过表达的目的。

2021年3月9日 · CD19-Cre and Mb1-iCre transgenic mice are commonly used for generating B cell-specific KO mice and investigate the development, as well as the physiological and pathophysiological roles of B cells. However, the CD19-Cre line low efficiency and the Mb1-iCre line occasional ectopic recombination represent challenges for their use.