CD151 molecule (Raph blood group), also known as CD151 (C luster of D ifferentiation 151), is a human gene. [5] The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

2024年12月24日 · CD151 (CD151 Molecule (Raph Blood Group)) is a Protein Coding gene. Diseases associated with CD151 include Epidermolysis Bullosa Simplex 7, With Nephropathy And Deafness and Raph Blood Group System. Among its related pathways are Cell junction organization and Collagen chain trimerization.

2025年3月21日 · As a member of the tetraspanin superfamily, CD151 plays a pivotal role in tumorigenesis, progression, and metastasis. CD151 is involved in various cellular processes, including cell-cell junction, signal transduction, epithelial-mesenchymal transition (EMT), cancer stem cell maintenance (CSCs), angiogenesis, and exosome regulation.

迁移体标志物CD151，作为Tetraspanins（TM4SF）家族的一员，具有独特的生物学功能。 该家族蛋白能够与自身及细胞表面分子结合，从而形成富含Tetraspanin的微结构域（TEM）。 TEM通过调控信号转导、细胞粘附、迁移、增殖和分化等过程，对癌细胞的迁移、侵袭、血管生成以及上皮间质转化（EMT）产生深远影响，进而推动肿瘤的发展。 近期研究进一步揭示了迁移体在营造利于血管生成的环境以及增强血管形成能力方面的关键作用。 鉴于血管生成在肿瘤转移中的核心 …

2013年11月18日 · CD151 regulates post-adhesion events, that is, cell spreading, migration and invasion including subsequent intravasation and formation of metastasis. Present on both neoplastic and endothelial...

CD151是四跨膜蛋白超家族(transmembrane 4 superfamily，TM4SF)中的一个成员，它能将整合素接收到的生物信号转导到细胞内的其他关键蛋白质(如激酶)，参与细胞的黏附、迁移、形成半桥粒结构等多种病理生理过程，在肿瘤细胞的迁移、侵袭和转移中起重要作用，其过 ...

CD151 分子 (Raph 血型)： 由该基因编码的蛋白质是跨膜 4 超家族的成员，也称为四跨膜蛋白家族。 这些成员中的大多数是细胞表面蛋白，其特征在于存在四个疏水结构域。

2023年5月1日 · CD151 is a transmembrane protein implicated in tumor progression and has been shown to regulate various cellular and molecular mechanisms contributing to malignancy. More recently, the role of CD151 in the tumor immune microenvironment (TIME) has gained attention as a potential target for cancer therapy.

CD151 regulates α6β4 distribution by enhancing protein kinase Cα (PKCα)—α6β4 integrin association and PKC-dependent β4 S1424 phosphorylation. CD151 in complex with PKCα enhances invasive behavior by phoshorylating β4 integrin, thus affects subcellular localization and epithelial disruption.

CD151 regulates post-adhesion events, that is, cell spreading, migration and invasion including subsequent intravasation and formation of metastasis. Present on both neoplastic and endothelial cells, CD151 is engaged in promotion of tumour neovascularization.