2021年8月23日 · 称为“B细胞辅助嗜中性粒细胞”（NBH细胞），该亚群（CD15 int/lo 、CD16 int/low 、CD11b hi ）被认为可促进B细胞增殖和抗体产生。 中性粒细胞迁移到组织后可以返回血流，这一过程称为反向跨内皮迁移。

The CD15 antigen is expressed on mature granulocytes and on myeloid cells from the promyelocyte stage onwards. Anti-CD15 antibody reacts with promyelocytes, and less strongly with myelocytes and metamyelocytes, but not bone marrow myeloblasts, as detected by flow cytometric analysis and an immunohistochemical method (10, 11, 36).

In human leukocytes, CD15 is expressed preferentially in monocytes, ma-ture neutrophils, and all myeloid cells from the promyelocyte stage onwards, making it a useful cell surface marker (9–11).

The glycan determinant Lewis x (Lex/CD15) is a distinguishing marker for human myeloid cells and mediates neutrophil adhesion to dendritic cells. Despite broad interest in this structure, the mechanism(s) underlying Lex/CD15 expression remain ...

The induced MDSCs are CD11b + CD33 + HLA-DR −/low and are heterogeneous for CD15 and CD14 expression. The induced MDSCs abrogate IL2 production and activation-induced cell death of the human T cell line Jurkat stimulated by CD3/CD28 antibodies, whereas the induced neutrophils enhance IL2 production from Jurkat cells.

Here, we report that cancer-related CD15/FUT4 is overexpressed in most of mCRCs patients (43 %) and associates with lower intratumoral CD3+ and CD8+ T cells, higher systemic inflammation (NLR at diagnosis >5) and poorer outcomes, in terms of response and progression-free survival than those CD15/FUT4-low or negative ones (adjusted hazard ratio (...

2008年10月19日 · The glycan determinant CD15 (also known as Lewis x, or Lex) is a distinguishing marker for human myeloid cells and mediates neutrophil adhesion to dendritic cells.

2018年5月1日 · For chimerism analysis, direct-tissue PCR is possible with the use of a robust, commercially available PCR mix containing a DNA polymerase capable of DNA amplification directly from the sample without the need for pretreatment.

1997年1月1日 · Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed an increase in steady-state TNF-α mRNA after 3 to 4 hours of cross-linking. CD15 cross-linking also concomitantly increased interleukin-1β (IL-1β) mRNA, while no apparent change was observed in the levels of β-actin mRNA, indicating specificity.

CD15 + and CD15 − samples from five independent Ptc +/− tumors (distinct from those used for microarray analysis) were analyzed by quantitative RT-PCR using primers for the indicated genes. Gene expression was normalized based on actin levels.