Here, we report that cancer-related CD15/FUT4 is overexpressed in most of mCRCs patients (43 %) and associates with lower intratumoral CD3+ and CD8+ T cells, higher systemic inflammation (NLR at diagnosis >5) and poorer outcomes, in terms of response and progression-free survival than those CD15/FUT4-low or negative ones (adjusted hazard ratio (...

2022年11月8日 · Here the authors show that tumor infiltrating neutrophils expressing high levels of CD15 interact with CD8+ T effector memory skewing them to produce GZMK, associated with tumor progression in...

2013年5月29日 · Flow-cytometry analysis of CRC cell suspensions derived from clinical specimens showed that while MPO+ cells were largely CD15+/CD66b+, sizeable percentages of CD15+ and CD66b+ cells were MPO−. High density MPO+ cell infiltration is a novel independent favorable prognostic factor in CRC.

2024年8月2日 · Here, we observed an increase in a population of monocytes expressing CD15 within the M-MDSC compartment of pts with colon cancer (CRC) in both PB and tumor tissues. Phenotypical and morphological analysis revealed that these CD15+ monocytes share both monocytic and neutrophilic properties and are associated with an increase in circulating GMPs.

2019年1月22日 · To understand how ERKs and JAK/STAT5 signaling regulates CD15/FUT4 and LY6G6D function, we first investigated the treatment response of human CRC cells (N = 38) to the MEK inhibitor, Trametinib, and the JAK1/2 inhibitor, ruxolitinib, by integrating genomic and transcriptomic data from the Cancer Cell Line Encyclopedia (CCLE) and Genomics of ...

2013年5月29日 · Flow-cytometry analysis of CRC cell suspensions derived from clinical specimens showed that while MPO+ cells were largely CD15+/CD66b+, sizeable percentages of CD15+ and CD66b+ cells were MPO-. Conclusions: High density MPO+ cell infiltration is a novel independent favorable prognostic factor in CRC.

2013年8月26日 · The aim of this study was to examine the expression of CD10 and CD15 in tumor cells, stromal cells, and infiltrating inflammatory cells during CRC development, investigate their expression levels between the tumor center and the invasive front and compare them to clinicopathological parameters in invasive CRC.

Background: The aim of this study was to examine the expression of CD10 and CD15 in tumor cells, stromal cells and infiltrating inflammatory cells during colorectal carcinoma (CRC) development and to investigate their expression levels between the tumor center and invasive front and compare them to clinicopathological parameters in invasive CRC.

2022年11月8日 · Here, we describe that the interaction of tumor infiltrating neutrophils expressing high levels of CD15 with CD8 + T effector memory cells (TEM) correlates with tumor progression. Mechanistically, stromal cell-derived factor-1 (CXCL12/SDF-1) promotes the retention of neutrophils within tumors, increasing the crosstalk with CD8 + T cells.

2013年8月1日 · The aim of this study was to examine the expression of CD10 and CD15 in tumor cells, stromal cells and infiltrating inflammatory cells during colorectal carcinoma (CRC) development and to...