CD122 is highly expressed on antigen-specific memory CD8 + T cells. High levels of CD122 expression distinguish memory CD8 + T cells and NK cells . Consistent with previous reports, …

CD8 + CD122 + T-cells have been traditionally described as antigen-specific memory T-cells that respond to previously encountered antigens more quickly and vigorously than their naïve …

2018年10月1日 · Here we demonstrate that costimulation-independent T cell alloreactivity relies on signaling through CD122, the shared IL-2 and IL-15 receptor β-chain. Combined …

Here, we show that the availability of IL-2Rβ (CD122), which is a receptor subunit shared by IL-2 and IL-15, affects both the cytokine responsiveness and the LIP of naïve CD4 T cells in the …

2018年1月25日 · We find that in vivo administration of an anti-CD122 mAb (CD122 blockade) restores immune tolerance in nonobese diabetic (NOD) mice via multiple mechanisms. First, …

2024年10月15日 · Discover the critical role of CD122 in modulating T cell responses for immunotherapy. This in-depth exploration covers how antibodies like TM-β1 target CD122 to …

2015年10月19日 · Human CD8(+)CXCR3(+) T-cells are the equivalent of murine CD8(+)CD122(+) Tregs and also exhibit central memory phenotypes. In this mini-review …

2013年6月13日 · We identified CD8 + CD122 + regulatory T cells (CD8 + CD122 + Treg cells) and reported their importance in maintaining immune homeostasis. The absence of CD8 + …

Findings present CD122-targeted IL-2 complexes as an advancement in cancer immunotherapy, as they reduce Treg immunosuppression, improve anti-cancer immunity, and boost PD-L1 …

These cells, identified as expressing both PD-1 (programmed death-1; CD279) and CD122 (IL-2Rβ chain), have been shown to be important in producing IL-10 and suppressing neighboring …