2018年2月15日 · Here, we unravel how the Mon1-Ccz1 guanosine exchange factor (GEF) acting upstream of Ypt7 is specifically recruited to the pre-autophagosomal structure under starvation …

2022年1月24日 · We found that over-expression of CCZ1-MON1A significantly increased the protein level of LC3-II and reduced SQSTM1 level in 3xTg AD mice and WT mice (Figure 8A …

2025年2月24日 · As expected, CCZ1 knockdown, like AP1-C treatment (Fig. 3G) or defects in RAB5 or RAB7 (Fig. 5, 6), significantly inhibited LD degradation, manifested by the increased …

Mon1-Ccz1 thereby mediates Rab5-dependent recruitment of Rab7, a process termed “Rab conversion” (Figure 4; Rink et al., 2005). Binding of Mon1-Ccz1 to LC3 proteins also promotes …

CCZ1-MON1A was activated during autophagy and positively regulates autophagosome maturation. (A-B) GTP-RAB7 in autophagosomes isolated from normal and HBSS-treated N2a …

Finally, to assess the importance of the Mon1–Ccz1–RMC1 assembly in regulating autophagy in zebrafish, we examined the expression level of p62 and LC3 in embryos coinjected with RMC1 …

Conclusions: Our data reveals that CCZ1-MON1A-RAB7 complex dysfunction is a potential mechanism for autophagosome maturation defects in AD, and advances the possibility that …

氯喹可以通过抑制溶酶体功能（比如升高它的pH值），抑制LC3-II的降解；巴佛洛霉素A1则是一种强效V-ATPase抑制剂，阻断溶酶体依赖的降解。 在“堵漏”的前提下，根据一段时间内LC3-II …

Here, we unravel how the Mon1-Ccz1 guanosine exchange factor (GEF) acting upstream of Ypt7 is specifically recruited to the pre-autophagosomal structure under starvation conditions. We …

2018年2月15日 · Here we have uncovered a simple molecular mechanism that specifically targets the GEF Mon1-Ccz1 onto the surface of autophagosomes. The Ccz1 subunit has at least one …