Chemokine (C-C motif) ligand 6 (CCL6) is a small cytokine belonging to the CC chemokine family that has only been identified in rodents. In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, and can be greatly induced under conditions suitable for …

其中CCR亚族已克隆11种（CCR1-CCR11），CXCR亚族6种（CXCR1 -CXCR6），另俩个亚族分别各有1种：XCR1和CX3CR1。 趋化因子与其受体之间交叉作用，形成复杂的网络关系，即一种趋化因子可与多个受体结合，一个受体也可以有多个高亲和的趋化因子配体。

2023年4月12日 · CCL6是一种趋化因子，也称为C-C motif ligand 6，是一种由细胞分泌的蛋白质。 它主要参与身体内免疫和炎症反应过程中的调节，能够诱导和促进白细胞的运动和趋化到炎症部位，从而加速炎症反应的发生和消退。

CCL6 存在于各种慢性炎症性疾病中，包括实验性脱髓鞘疾病、过敏性气道炎症、博莱霉素引起的肺纤维化和慢性腹膜炎。 CCL6 还可作为小鼠急性腹膜炎中的单核细胞螯合剂 [2]。

CCL6 is a CC chemokine that was cloned in the mouse in 1991. Gene synonyms for CCL6 include MRP-1, Scya6 and C10. Although a human homolog has not been described to date, this novel chemokine shares significant homology with the human CC chemokine, CCL15.

2025年2月8日 · Chemokine CCL6 Plays Key Role in the Inhibitory Effect of Vitamin A on Norovirus Infection. CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3-kinase/Akt signalling pathway during skin wound healing. Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 …

2022年12月2日 · In this study, we assess the role of chemokine (C-C motif) ligand 6 (CCL6) in modulating macrophage polarization and wound healing. Initially, we observed significantly upregulated CCL6 expression in the skin tissue on the edge of the wound during the inflammation and proliferation phases.

2021年5月26日 · Mechanistically, eosinophils promote tumor cell migration and metastasis formation through secreting C-C motif chemokine ligand 6 (CCL6). Genetic knockout of Ccl6 in Il-5 Tg mice remarkably attenuates bone metastasis.

2007年10月15日 · Recent studies showed that the CC chemokine CCL6 enhanced antimicrobial immunity during experimental sepsis through an unknown mechanism.

2022年12月10日 · ScRNAseq of the neutropenic bone marrow predicted cellular crosstalk between mature neutrophils expressing CCL6, a known chemoattractant for interferon-producing NK cells, and activated Ccr2 ...