The caveolins are similar in structure. They all form hairpin loops that are inserted into the cell membrane. Both the C-terminus and the N-terminus face the cytoplasmic side of the membrane. There are two isoforms of caveolin-1: caveolin-1α and caveolin-1β, …

Caveolin-1是一种细胞表面的穴样内陷（caveolae）中的主要膜内在蛋白，在保持caveolae的完整性、小胞的运输、信号的传导中起一定的作用。 微囊是细胞膜上脂筏表面的一种特殊的细胞内凹陷。

2024年6月19日 · Caveolin 是一类小分子膜蛋白，在形成细胞膜的小窝（caveolae）结构中起关键作用。 Caveolae是富含胆固醇和鞘脂的小凹陷区域，参与多种细胞过程，包括信号传导、脂质代谢、内吞作用和细胞保护

2022年5月11日 · Cryo–electron microscopy reveals the structure of caveolin, the major membrane protein of caveolae, providing new insights into how this critical protein works.

哺乳动物细胞 能够表达三种caveolin蛋白，分别是caveolin-1，caveolin-2，和caveolin-3 。 这三种蛋白具有共同结构，N端和C端都游离于细胞质中，中间是呈发夹结构的跨膜结构域。

Interestingly, caveolin-1 has emerged as a key regulator of different forms of cellular senescence. Here, we provide a comprehensive description of the signaling pathways and molecular mechanisms through which caveolin-1 controls the development of a senescent phenotype and the role of caveolin-1-mediated cellular senescence in cancer.

小窝内吞（Caveolae-Mediated Endocytosis）是一种特定的内吞途径，通过细胞膜上的小窝结构（caveolae）将物质内化到细胞内部。 小窝是细胞膜上的微小凹陷区域，富含胆固醇、鞘脂和特定蛋白（如小窝蛋白caveolin）。

Caveolins (Cavs) are integrated plasma membrane proteins that are complex signaling regulators with numerous partners and whose activity is highly dependent on cellular context. Cavs are both positive and negative regulators of cell signaling in and/or out of caveolae, invaginated lipid raft domains whose formation is caveolin expression dependent.

2024年7月6日 · Caveolins are a family of transmembrane proteins located in caveolae, small lipid raft invaginations of the plasma membrane. The roles of caveolin-enriched lipid rafts are diverse, and include mechano-protection, lipid homeostasis, metabolism, transport, and cell signaling.

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