Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, [5] critical to the apoptotic pathway found in many tissues. [6] Caspase-9 homologs have been …

胱天蛋白酶9 （英语：Caspase 9）是人类中由 CASP9 基因 编码的一种 酶。 它是一种启动型 胱天蛋白酶， [6] 对于许多组织中发现的细胞凋亡途径至关重要。 [7] 已经在已知存在的所有 哺 …

在细胞凋亡途径中，始发性Caspase（如Caspase-9）或其他信号传导分子被激活后，它们可以进一步活化Caspase-7，从而引发一系列细胞凋亡的关键事件。 一旦Caspase-7被激活，它能够 …

2023年12月8日 · Caspase 是一组存在于细胞质中的蛋白酶，全称为含半胱氨酸的天冬氨酸蛋白水解酶（cysteinyl aspartate specific proteinase），它们被激活后能够在靶蛋白的特异天冬氨酸 …

Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria …

2017年4月4日 · As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including …

Caspase-9 undergoes autocatalytic cleavages on binding to the apoptosome, but the cleaved caspase-9 is only catalytically activated when bound to the apoptosome, prompting the …

2024年12月24日 · CASP9 (Caspase 9) is a Protein Coding gene. Diseases associated with CASP9 include Acute Promyelocytic Leukemia and Colorectal Cancer. Among its related …

2025年2月9日 · Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing …

Caspase-9 is the upstream caspase that is activated when cytochrome c is released from the mitochondria in response to various forms of stress or death signals.